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细胞信号转导
Loperamide HCl
| 品牌 | 厂商性质 | 产地 | 货期 |
|---|---|---|---|
| 阿拉丁 | 生产商 | 上海 | 现货 |
产品参数
| 货号 | CAS号 | 操作 |
|---|---|---|
| L129465-25g | 34552-83-5 | 询价 |
| L129465-5g | 34552-83-5 | 询价 |
产品介绍
- 分子式 C29H33ClN2O2·HCl
- 分子量513.50
- EC号 252-082-4
- MDL号 MFCD00058581
- PubChem编号 24278042
属性
| 熔点 | 223°C |
| 溶解性 | Soluble in water (160 mg/ml), methanol (286 mg/ml), ethanol (53.7 mg/ml), DMSO (205 mg/ml), and chloroform. |
描述
| 应用 | A Ca2+ channel protein inhibitor and MOR activator. |
| 产品介绍 | Loperamide HCl是一种阿片受体激动剂，ED50为0.15 mg/kg。 |
| 备注 | Loperamide HCl is an opioid-receptor agonist with an ED50 of 0.15 mg/kg. |
| 生化机理 | Loperamide Hydrochloride is an opiate agonist with selectivity for the MOR (μ-opiod receptor). This specificity for μ-opioid receptors and limited penetrability into the brain prevent Loperamide from demonstrating central systemic effects generally associated with opiates, instead demonstrating localized action on the nociceptor and resultant antihyperalgesic action. Loperamide is shown to have an effect on the Ca2+ flux through high-voltage-activated calcium channels in response to high levels of extracellular K+, and at higher concentrations Loperamide is also a calcium channel protein inhibitor via the N-methyl-D-aspartate (NMDA) receptor-operated ion channel. |
| 别名 | 洛哌丁胺 盐酸盐;盐酸氯苯哌酰胺;4-(对氯苯基)-4-羟基-N,N-二甲基-α,α-二苯基-1-哌啶丁酰胺盐酸盐;盐酸洛哌丁胺;4-(p-Chlorophenyl)-4-hydroxy-N,N-dimethyl-α,α-diphenyl-1-piperidinebutyramide hydrochloride;Loperamide Hydrochloride;4-(4-Chlorophenyl)-4-hydroxy-N,N-dimethyl-α,α-diphenyl-1-piperidinebutanamide Hydrochloride;Imodium |
Loperamide HCl信息由上海阿拉丁生化科技股份有限公司为您提供，如您想了解更多关于Loperamide HCl报价、型号、参数等信息，欢迎来电或留言咨询。
注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途