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Azasetron HCl
| 品牌 | 厂商性质 | 产地 | 货期 |
|---|---|---|---|
| 阿拉丁 | 生产商 | 上海 | 现货 |
产品参数
| 货号 | CAS号 | 操作 |
|---|---|---|
| A129701-100mg | 123040-16-4 | 询价 |
| A129701-25mg | 123040-16-4 | 询价 |
| A129701-5mg | 123040-16-4 | 询价 |
产品介绍
属性
| 熔点 | 301-303 °C |
| 溶解性 | Soluble in water (25 mg/ml), and DMSO (10 mM). |
| 存贮条件 | 储存温度-20°C |
描述
| 应用 | A potent and selective SR-3 antagonist |
| 产品介绍 | Azasetron HCl是一种选择性5-HT3受体拮抗剂，IC50为0.33 nM，用于癌症化疗引起的恶心和呕吐。 |
| 备注 | Azasetron HCl is a selective 5-HT3 receptor antagonist with IC50 of 0.33 nM used in the management of nausea and vomiting induced by cancer chemotherapy. |
| 生化机理 | Y-25130 Hydrochloride is a potent and selective SR-3 antagonist. This product was demonstrated to be an antiemetic agent valuable for countering adverse effects seen in anticancer therapy including cisplatin. In studies involving rat hippocampal slices, Y-25130 exhibited dose-dependent neuroprotective effects against an ischemia-induced decrease in CA1 field potential. It has also been reported to attenuate the cocaine-induced decrease of intracranial self-stimulation (ICSS) reward thresholds in rats. Other results of the SR-3 antagonistic activity of Y-25130 led to the acceleration of gastric emptying in mice. |
| 别名 | 盐酸阿扎司琼; N-(1-氮杂双环[2.2.2]辛-8-基)-6-氯-4-甲基-3-氧代-3,4-二氢-2H-1,4-苯并恶嗪-8-甲酰胺盐酸盐;N-(1-Azabicyclo[2.2.2]octan-8-yl)-6-chloro-4-methyl-3-oxo-1,4-benzoxazine-8-carboxamide hydrochloride;Y-25130 hydrochloride; Y25130 hydrochloride; Y 25130 hydrochloride;Azasetron hydrochloride |
Azasetron HCl信息由上海阿拉丁生化科技股份有限公司为您提供，如您想了解更多关于Azasetron HCl报价、型号、参数等信息，欢迎来电或留言咨询。
注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途