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细胞信号转导
BAY 11-7082
品牌 | 厂商性质 | 产地 | 货期 |
---|---|---|---|
阿拉丁 | 生产商 | 上海 | 现货 |
产品参数
货号 | CAS号 | 操作 |
---|---|---|
B129693-50mg | 19542-67-7 | 询价 |
B129693-1g | 19542-67-7 | 询价 |
B129693-250mg | 19542-67-7 | 询价 |
产品介绍
- 分子式 C10H9NO2S
- 分子量207.25
- MDL号 MFCD00712162
- PubChem编号 24891842
属性
敏感性 | 对热、光和空气敏感 |
溶解性 | Soluble in DMSO (>25 mg/ml), ethanol (15 mg/ml), methanol, dichloromethane, DMF (~25 mg/ml), and 1:3 DMF:PBS (pH 7.2) (~0.25 mg/ml). Insoluble in water, and sparingly soluble in aqueous buffers. |
存贮条件 | 储存温度 2-8°C ,充氩储存 |
描述
应用 | An anti-inflammatory agent and NFκB inhibitor |
产品介绍 | BAY 11-7082是一种NF-κB抑制剂,抑制TNFα诱导的IκBα磷酸化,IC50为10 μM。同时对泛素化系统的组分也有抑制作用。 |
备注 | BAY 11-7082 is a NF-κB inhibitor, inhibits TNFα-induced IκBα phosphorylation with IC50 of 10 μM. |
生化机理 | BAY 11-7082, a potential anti-inflammatory agent, is an irreversible inhibitor of IKK α and phosphorylation of cytokine-inducible IκBα (nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-α, NFKBIA; IC50=10 μM). In intact HUVECs, it inhibits TNFα-induced phosphorylation and degradation of IκBa (NFKBIA) without affecting constitutive phosphorylation. Inhibition of ιBα phosphorylation and degradation results in the inactivation of NFκB and thereby inhibits the expression of endothelial-leukocyte adhesion molecules: E-selectin, VCAM-1 and ICAM-11. BAY 11-7082 has also demonstrated stimulation of the stress-activated protein kinases, p38 and JNK-1. |
别名 | (E)-3-(对甲苯磺酰基)丙烯腈; (E)-3-甲苯磺酰基丙烯腈;(2E)-3-[(4-甲基苯基)磺酰基]-2-丙烯腈;(E)-3-(4-Methylphenylsulfonyl)-2-propenenitrile;(E)-3-Tosylacrylonitrile;(E)-3-(p-Toluenesulfonyl)acrylonitrile |
BAY 11-7082信息由上海阿拉丁生化科技股份有限公司为您提供,如您想了解更多关于BAY 11-7082报价、型号、参数等信息,欢迎来电或留言咨询。
注:该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案,不可用于临床诊断或治疗等相关用途