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ARN-509
品牌 | 厂商性质 | 产地 | 货期 |
---|---|---|---|
阿拉丁 | 生产商 | 上海 | 现货 |
产品参数
货号 | CAS号 | 操作 |
---|---|---|
A127949-100mg | 956104-40-8 | 询价 |
A127949-25mg | 956104-40-8 | 询价 |
A127949-5mg | 956104-40-8 | 询价 |
产品介绍
属性
溶解性 | DMSO 15 mg/mL Ethanol 5 mg/mL |
存贮条件 | 储存温度-20°C |
描述
产品介绍 | ARN-509是竞争性雄激素受体抑制剂,IC50为16 nM,可作用于前列腺癌。 |
生化机理 |
ARN-509 is an androgen receptor antagonist with potential antineoplastic activity. ARN-509 binds to AR in target tissues thereby preventing androgen-induced receptor activation and facilitating the formation of inactive complexes that cannot be translocated to the nucleus. This prevents binding to and transcription of AR-responsive genes. This ultimately inhibits the expression of genes that regulate prostate cancer cell proliferation and may lead to an inhibition of cell growth in AR-expressing tumor cells. |
别名 | ARN 509; ARN509;ARN 509; ARN509;4-(7-(6-cyano-5-(trifluoromethyl)pyridin-3-yl)-8-oxo-6-thioxo-5,7-diazaspiro(3.4)octan-5-yl)-2-fluoro-n-methylbenzamide |
ARN-509信息由上海阿拉丁生化科技股份有限公司为您提供,如您想了解更多关于ARN-509报价、型号、参数等信息,欢迎来电或留言咨询。
注:该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案,不可用于临床诊断或治疗等相关用途