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Glyburide
| 品牌 | 厂商性质 | 产地 | 货期 |
|---|---|---|---|
| 阿拉丁 | 生产商 | 上海 | 现货 |
| 货号 | CAS号 | 操作 |
|---|---|---|
| G127198-25g | 10238-21-8 | 询价 |
| G127198-5g | 10238-21-8 | 询价 |
| G127198-100g | 10238-21-8 | 询价 |
- 分子式 C23H28ClN3O5S
- 分子量494
- Beilstein号
- EC号 233-570-6
- MDL号 MFCD00056625
- PubChem编号 24277838
属性
| 熔点 | 171-174°C |
| 折光率 | 1.62 |
| 敏感性 | 对热敏感 |
| 溶解性 | Soluble in ethanol (5 mg/mL), DMSO (25 mg/mL), chloroform (1:36), methanol (1:250), and DMF. Insoluble in water. |
| 存贮条件 | 储存温度2-8℃ |
| 密度 | 1.4000 |
描述
| 应用 | An ATP-dependent KIR6 and CFTR Cl- channel blocker |
| 产品介绍 | Glibenclamide (格列本脲; Glyburide) 是磺酰脲类化合物，能调节胰岛素的产生。 |
| 备注 | Glyburide (Diabeta) is an anti-diabetic compound in a class of medications known as sulfonylureas, closely related to sulfa agents. |
| 生化机理 |
Glibenclamide is a sulfonylurea compound that modulates insulin production. Sulfonylureas bind to ATP-dependent K+ channels in beta cells of the pancreas, depolarizing them and stimulating the release of Ca2+, which in turn stimulates insulin production. Glibenclamide, a sulphonylurea oral hypoglycaemic agent is a widely used antagonist of cromakalim-activated K+ channels in smooth muscle. Binding of Gli to SUR produces the closure of KATP channels and the inhibition of their activity. Glibenclamide is widely used for treatment of type 2-diabetes and it has been signaled as antiproliferative in several tumor cell lines. |
| 别名 | 格列本脲;优降糖; 5-氯-N-[4-(环己基脲磺酰)苯乙基]-2-甲氧基苯甲酰胺; N-对[2-(5-氯-2-甲氧基苯甲酰氨基)乙基]苯磺酰基-N′-环己基脲; 5-氯-N-[4-(3-环己基脲基磺酰基)苯基乙基]-2-甲氧基苯甲酰胺;Glyburide;5-Chloro-N-[4-(3-cyclohexylureidosulfonyl)phenethyl]-2-methoxybenzamide;N-p-[2-(5-Chloro-2-methoxybenzamido)ethyl]benzenesulfonyl-N′-cyclohexylurea |
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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途