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LUF6000
品牌 | 厂商性质 | 产地 | 货期 |
---|---|---|---|
阿拉丁 | 生产商 | 上海 | 现货 |
货号 | CAS号 | 操作 |
---|---|---|
L127479-50mg | 890087-21-5 | 询价 |
L127479-100mg | 890087-21-5 | 询价 |
L127479-5mg | 890087-21-5 | 询价 |
L127479-10mg | 890087-21-5 | 询价 |
- 分子式 C22H20Cl2N4
- 分子量411.33
属性
溶解性 | DMSO |
存贮条件 | 储存温度-20°C |
描述
生化机理 |
LUF6000 is an allosteric modulator of the human A3 adenosine receptor (AR). LUF6000 was found to be an allosteric enhancer of Emax of structurally diverse agonists at the A3 AR, being more effective for low-Emax agonists than for high-Emax agonists. LUF6000 exerted an Emax-enhancing effect at a concentration of 0.1 microM or higher, and was shown to increase the Emax of Cl-IB-MECA and other low-efficacy agonists to a larger extent than that of the high-efficacy agonist NECA. Interestingly, LUF6000 converted a nucleoside A3 AR antagonist MRS542, but not a non-nucleoside antagonist MRS1220, into an agonist. |
别名 | ; |
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注:该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案,不可用于临床诊断或治疗等相关用途