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其他小分子
Glimepiride
| 品牌 | 厂商性质 | 产地 | 货期 |
|---|---|---|---|
| 阿拉丁 | 生产商 | 上海 | 现货 |
产品参数
| 货号 | CAS号 | 操作 |
|---|---|---|
| G129354-1g | 93479-97-1 | 询价 |
| G129354-25g | 93479-97-1 | 询价 |
| G129354-5g | 93479-97-1 | 询价 |
产品介绍
-
分子式
C24H34N4O5S
- 分子量490.62
- Beilstein号
- EC号 MFCD00878417
- MDL号 MFCD00878417
- PubChem编号
属性
| 溶解性 | Soluble in DMSO (>10 mg/ml), water (<1 mg/ml at 25 °C), and ethanol (<1 mg/ml at 25 °C). |
描述
| 应用 | A third generation sulfonylurea compound that induces the PI3K and Akt pathway |
| 产品介绍 | Glimepiride is a third generation sulfonylurea compound, which increases the release of insulin from pancreatic beta cells. In addition, Glimepiride increases the activity of intracellular insulin receptors. Studies conducted on adipocytes and skeletal muscle suggest that Glimepiride induces the PI3 kinase (PI3K) and Akt pathway, along with insulin receptor substrate-1/2 and endothelial nitric oxide synthase. Glimepiride also increases osteoblast proliferation and differentiation, which is thought to be related to its ability to activate the PI3K and Akt pathway. Furthermore, Glimepiride enhances intrinsic peroxisome proliferator-activated receptor γ activity. Glimepiride also increases protein expression of glucose transports 1 and 4, and is a potent KIR channel blocker. |
| 别名 | 贺普丁;格列美脲;格列吡咯;1-[4-[2-(3-乙基-4-甲基-2-氧代-3-吡咯啉-1-甲酰胺基)-乙基]-苯磺酰]-3-(反式-4-甲基环己基)-脲;反式-3-乙基-2,5-二氢-4-甲基-N-[2-[4-[[[[(4-甲基环己基)氨基]羰基]氨基]磺酰基]苯基]乙基]-2-氧-1H-吡咯-1-羧酰胺; |
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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途