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Camostat Mesilate
| 品牌 | 厂商性质 | 产地 | 货期 |
|---|---|---|---|
| 阿拉丁 | 生产商 | 上海 | 现货 |
产品参数
| 货号 | CAS号 | 操作 |
|---|---|---|
| C129276-100mg | 59721-29-8 | 询价 |
| C129276-10mg | 59721-29-8 | 询价 |
| C129276-1g | 59721-29-8 | 询价 |
| C129276-250mg | 59721-29-8 | 询价 |
| C129276-25mg | 59721-29-8 | 询价 |
| C129276-50mg | 59721-29-8 | 询价 |
产品介绍
- 分子式 C20H22N4O5.CH4O3S
- 分子量494.52
- Beilstein号
- EC号 MFCD00941410
- MDL号 MFCD00941410
- PubChem编号
属性
| 熔点 | 164-168° |
| 溶解性 | Soluble in water (100 mM), DMSO (100 mM), and ethanol (<1 mg/ml). |
| 存贮条件 | 储存温度 2-8°C |
描述
| 应用 | A protease and Trypsin inhibitor. |
| 产品介绍 | Camostat Mesilate是胰蛋白酶样的蛋白酶抑制剂，抑制上皮细胞钠离子通道(ENaC)功能，IC50为50 nM, 对Trypsin, Prostasin 和 Matriptase作用效果稍弱。 |
| 备注 | Camostat is a trypsin-like protease inhibitor, inhibits airway epithelial sodium channel (ENaC) function with IC50 of 50 nM, less potent to trpsin, prostasin and matriptase. |
| 生化机理 | Camostat mesylate, a protease inhibitor, has been found to cause significant increase in the bicarbonate concentration, secretory rate, and output of pancreatic juice of dogs. Furthermore it was found that this water induction and bicarbonate secretion increase was achieved via direct regulation of ductular cells of the dog pancreas. Other studies have shown Camostat mesylate to suppress spinal Fos expression in the rat, which is a marker for neuronal activation. In addition it was shown that this compound may prevent or depress pancreatitis-induced referred allodynia/hyperalgesia in rat models. Camostat mesylate has also demonstrated the ability to prevent Trypsin attack of microspheres, which causes the degradation product N-benzoyl-dl-arginine. Camostat mesylate is an inhibitor of KLK, plasminogen, Prothrombin and Trypsin. |
| 别名 | 甲磺酸卡莫司他; 2-(二甲基氨基)-2-氧代乙基 4-(4-胍基苯甲酰氧基)苯乙酸酯甲磺酸盐; FOY305; FOY-S980;FOY305; FOY-S980; Foipan mesylate;4-[[4-[(Aminoiminomethyl)amino]benzoyl]oxy]benzeneacetic acid 2-(dimethylamino)-2-oxoethyl ester methanesulfonate;2-(Dimethylamino)-2-oxoethyl 4-(4-guanidinobenzoyloxy)phenylacetate methanesulphonate |
Camostat Mesilate信息由上海阿拉丁生化科技股份有限公司为您提供，如您想了解更多关于Camostat Mesilate报价、型号、参数等信息，欢迎来电或留言咨询。
注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途