诚信认证：
工商注册信息已核实！
快速导航
产品分类
微信二维码
Minisite
QQ号咨询
其他小分子
UNC1215
| 品牌 | 厂商性质 | 产地 | 货期 |
|---|---|---|---|
| 阿拉丁 | 生产商 | 上海 | 现货 |
产品参数
| 货号 | CAS号 | 操作 |
|---|---|---|
| U125324-5mg | 1415800-43-9 | 询价 |
| U125324-100mg | 1415800-43-9 | 询价 |
| U125324-25mg | 1415800-43-9 | 询价 |
产品介绍
- 分子式 C32H43N5O2
- 分子量529.72
属性
| 溶解性 | 25°C: DMSO |
| 存贮条件 | 储存温度-20°C |
描述
| 产品介绍 | UNC1215是选择性MBT (恶性脑瘤)拮抗剂，与L3MBTL3结合，IC50为40 nM，Kd为120 nM。 |
| 生化机理 | UNC1215 binds L3MBTL3 with a K(d) of 120 nM, competitively displacing mono- or dimethyllysine-containing peptides, and is greater than 50-fold more potent toward L3MBTL3 than other members of the MBT family while also demonstrating selectivity against more than 200 other reader domains examined. X-ray crystallography identified a unique 2:2 polyvalent mode of interaction between UNC1215 and L3MBTL3. In cells, UNC1215 is nontoxic and directly binds L3MBTL3 via the Kme-binding pocket of the MBT domains. UNC1215 increases the cellular mobility of GFP-L3MBTL3 fusion proteins, and point mutants that disrupt the Kme-binding function of GFP-L3MBTL3 phenocopy the effects of UNC1215 on localization. |
| 别名 | UNC 1215;UNC-1215; 1,1'-[2-(苯基氨基)-1,4-亚苯基]二[1-[4-(1-吡咯烷基)-1-哌啶基]甲酮];UNC 1215;UNC-1215; 1,1'-[2-(Phenylamino)-1,4-phenylene]bis[1-[4-(1-pyrrolidinyl)-1-piperidinyl]methanone]; 2-Phenylamino-1,4-[4-(pyrrolidinyl)piperidinyl)benzamide |
UNC1215信息由上海阿拉丁生化科技股份有限公司为您提供，如您想了解更多关于UNC1215报价、型号、参数等信息，欢迎来电或留言咨询。
注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途