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Trifluridine

品牌 厂商性质 产地 货期
阿拉丁 生产商 上海 现货

在线咨询 询底价
产品参数
货号 CAS号 操作
T129222-1g 70-00-8 询底价
T129222-50mg 70-00-8 询底价
T129222-250mg 70-00-8 询底价
T129222-100mg 70-00-8 询底价
产品介绍

  • 分子式 C10H11F3N2O5
  • 分子量296.20
  • Beilstein号
  • EC号
  • MDL号 MFCD00006534
  • PubChem编号

属性

熔点 189°C
旋光率 +47.0 ~ +53.0°(C=1,H2O)
敏感性 对湿度敏感
溶解性
  • DMSO 59 mg/mL
  • Water 59 mg/mL
  • Ethanol 59 mg/mL
  • 存贮条件 储存温度 -20°C;充氩保存

    描述

    应用 三氟胸苷 (TFT) 是一种用于研究胸苷激酶特异性和动力学的底物。磷酸化后的 TFT 可掺入 DNA,诱导 DNA 损伤,因此 TFT 可用于研究 DNA 修复机制。TFT 也可用于研究胸苷酸合成酶抑制机制。
    产品介绍 Trifluridine 是一种抗疱疹病毒药,主要用于眼部。
    备注 Trifluridine (Viroptic) is an anti-herpesvirus antiviral agent used primarily on the eye.
    生化机理

    Description:
    IC50 Value: 1 uM ( Hela cell) [1]
    Trifluridine (also called trifluorothymidine or TFT) is an anti-herpesvirus antiviral drug, used primarily on the eye. Trifluorothymidine (TFT) is well known to be converted to TFT-monophosphate by thymidine kinase and to inhibit thymidylate synthase
    in vitro: When HeLa cells were treated with TFT at a concentration of 1 ?M (IC50 value), the concentration of TFT in the DNA was calculated as 62.2±0.9 pmol/1x106 cells for 4 h [1]. Unlike FdUrd and 5FU, TFT resulted in an earlier phosphorylation of ATR and chk1 proteins after only 24 h of exposure, while phosphorylated ATM, BRCA2 and chk2 proteins were detected after more than 48 h of exposure to TFT [2]. SN38 and TFT induced most DNA damage in H630 and Colo320 cells, which was increased in combination. TFT pre-incubation further enhanced SN38-induced DNA strand breaks in H630 and Colo320 (>20%), which was most pronounced in H630 cells (p<0.01) [3]

    别名 三氟胸苷;三氟尿苷;5-三氟甲-2-脱氧尿苷;三氟胸腺嘧啶核苷 ;α,α,α-三氟胸苷;2'-脱氧-5-三氟甲基尿苷;三氟胸腺嘧啶脱氧核苷; 曲氟尿苷;2'-Deoxy-5-trifluoromethyluridine;α,α,α-Trifluorothymidine;Trifluridine

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    注:该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案,不可用于临床诊断或治疗等相关用途