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Troglitazone
| 品牌 | 厂商性质 | 产地 | 货期 |
|---|---|---|---|
| 阿拉丁 | 生产商 | 上海 | 现货 |
产品参数
| 货号 | CAS号 | 操作 |
|---|---|---|
| T126362-50mg | 97322-87-7 | 询价 |
| T126362-10mg | 97322-87-7 | 询价 |
产品介绍
- 分子式 C24H27NO5S
- 分子量441.54
属性
| 存贮条件 | 储存温度-20°C |
描述
| 应用 | A potent antiproliferative, apoptosis inducer, antioxidant, and antiinflammatory agent |
| 产品介绍 | Troglitazone(CS-045)是PPARγ激动剂，具有抗炎抗癌活性。 |
| 生化机理 | Troglitazone has been shown to be a potent antiproliferative and apoptosis inducer. This compound has displayed a capacity to inhibit growth of HCC cells via G1 phase cell cycle arrest through hypophosphorylation of Rb (retinoblastoma) protein and an increase of the cyclin-dependent kinase inhibitors, p21 and p27 proteins. In addition, Troglitazone has been reported to have profound antioxidant and antiinflammatory effects, and found to suppress L-type and receptor operated Ca2+ channel and PKC (protein kinase C). Experiments have shown Troglitazone to bind and activate PPARγ(peroxisome proliferator-activated receptor γ). PPARγ is mainly expressed in adipose tissue, one of the target tissues for insulin, but has subsequently been found to be expressed in vascular smooth muscle cells, endothelial cells, macrophages, and some cancer cells. |
| 别名 | 曲格列酮; (+/-)-5-[4-[(6-羟基-2,5,7,8-四甲基苯并二氢吡喃-2-基)甲氧基]苄基]-2,4-噻唑烷二酮;Rezulin;CS-045;Noscal;(+/-)-5-[4-[(6-Hydroxy-2,5,7,8-tetramethylchroman-2-yl)methoxy]benzyl]-2,4-thiazolidinedione |
Troglitazone信息由上海阿拉丁生化科技股份有限公司为您提供，如您想了解更多关于Troglitazone报价、型号、参数等信息，欢迎来电或留言咨询。
注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途