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其他小分子
Teriflunomide
| 品牌 | 厂商性质 | 产地 | 货期 |
|---|---|---|---|
| 阿拉丁 | 生产商 | 上海 | 现货 |
产品参数
| 货号 | CAS号 | 操作 |
|---|---|---|
| T124990-5g | 163451-81-8 | 询价 |
| T124990-50mg | 163451-81-8 | 询价 |
| T124990-1g | 163451-81-8 | 询价 |
| T124990-250mg | 163451-81-8 | 询价 |
产品介绍
- 分子式 C12H9F3N2O2
- 分子量270.21
属性
| 溶解性 | Soluble in DMSO (32 mg/ml at 25 °C), methanol, DMF (~21.6 mg/ml), ethanol (1.35 mg/ml, sonication), and water (slightly). |
| 存贮条件 | 储存温度2-8℃ |
描述
| 产品介绍 | A77 1726, also known as teriflunomide, is the active metabolite of leflunomide. This compound has demonstrated antiinflammatory, antiproliferative, and immunosuppressive effects. A77 1726 has been shown to inhibit the proliferation of multiple mammalian cell lines in vitro, has demonstrated inhibition of Cox-2, dendritic cell function, DHODH (dihydroorotate dehydrogenase), and blocks TNF-dependent nuclear factor-κ B activation and gene expression. DHODH is an enzyme involved in the de novo synthesis of pyrimidine nucleotides, and its inhibition is thought to result in the antiproliferative effects on rapidly dividing cells, such as T-cells, observed by this compound. |
| 生化机理 | An active metabolite of leflunomide that inhibits Cox-2 |
| 别名 | 特立氟胺;SU 20;A 1726;A77-1726;A771726;Flucyamide;HMR 1726;(Z)-2-Cyano-3-hydroxy-N-[4-(trifluoromethyl)phenyl]-2-butenamide;N-(4-Trifluoromethylphenyl)-2-cyano-3-hydroxycrotoamide |
Teriflunomide信息由上海阿拉丁生化科技股份有限公司为您提供，如您想了解更多关于Teriflunomide报价、型号、参数等信息，欢迎来电或留言咨询。
注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途