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Simvastatin
| 品牌 | 厂商性质 | 产地 | 货期 |
|---|---|---|---|
| 阿拉丁 | 生产商 | 上海 | 现货 |
产品参数
| 货号 | CAS号 | 操作 |
|---|---|---|
| S129538-1g | 79902-63-9 | 询价 |
| S129538-25g | 79902-63-9 | 询价 |
| S129538-250mg | 79902-63-9 | 询价 |
| S129538-5g | 79902-63-9 | 询价 |
| S129538-100g | 79902-63-9 | 询价 |
产品介绍
- 分子式 C25H38O5
- 分子量418.57
- Beilstein号
- EC号
- MDL号 MFCD00072007
- PubChem编号 24724617
属性
| 熔点 | 134°C |
| 敏感性 | 对湿度和空气敏感 |
| 溶解性 | Soluble in DMSO (>25 mg/ml), ethanol (>25 mg/ml), water (0.03 mg/l), and methanol. |
| 存贮条件 | 储存温度 2-8°C ,充氩储存 |
描述
| 应用 | A HMGCR inhibitor and anti-proliferative agent. |
| 生化机理 | Simvastatin is an HMGCR (HMG-CoA reductase) inhibitor with anti-proliferative properties. This compound has been shown to modulate purified bovine pituitary 20 S proteasome via mild stimulation of chymotrypsin-like activity and inhibition of peptidylglutamylpeptide hydrolyzing activity. Mechanistic studies suggest that Simvastatin decreases CDK4 and CDK2 kinase activities and represses high glucose-induced Rho A (Rho GTPase)/p21 signaling in mesangial cells. Simvastatin also potentiates apoptosis in human myeloid leukemia cells via the suppression of TNF-induced NF-κB activation (IC50 ~ 13 μM). |
| 别名 | 塞瓦停;舒降脂;西伐斯汀;辛伐他汀; (1S,2S,6S,8S,8aR)-1,2,6,7,8,8a-六氢-3,7-二甲基-8-[2-[(2R,4R)-四氢-4-羟基-6-氧代-2H-吡喃-2-基]乙基]-1-萘酚 2,2-二甲基丁酸酯;MK 733; Simlup; Simcard; Simvacor; Simvoget; Zorced; Zocor;(1S,3R,7S,8S,8aR)-1,2,3,7,8,8a-Hexahydro-3,7-dimethyl-8-[2-[(2R,4R)-tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl]ethyl]-1-naphthalenyl 2,2-dimethyl-butanoate |
Simvastatin信息由上海阿拉丁生化科技股份有限公司为您提供，如您想了解更多关于Simvastatin报价、型号、参数等信息，欢迎来电或留言咨询。
注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途