诚信认证：
工商注册信息已核实！
快速导航
产品分类
微信二维码
Minisite
QQ号咨询
其他小分子
STF-62247
| 品牌 | 厂商性质 | 产地 | 货期 |
|---|---|---|---|
| 阿拉丁 | 生产商 | 上海 | 现货 |
产品参数
| 货号 | CAS号 | 操作 |
|---|---|---|
| S129300-5mg | 315702-99-9 | 询底价 |
| S129300-25mg | 315702-99-9 | 询底价 |
| S129300-100mg | 315702-99-9 | 询底价 |
产品介绍
- 分子式 C15H13N3S
- 分子量267.35
- MDL号 MFCD01121974
属性
| 沸点 | 444.82° C |
| 熔点 | 174.66° C |
| 折光率 | 1.67 |
| 溶解性 |
|
| 存贮条件 | 储存温度-20°C |
| 密度 | 1.2600 |
描述
| 应用 | STF-62247 may be used as positive control in autophagy inducing cell signaling studies. |
| 产品介绍 | STF-62247是一个TGN抑制剂，在RCC4 和RCC4/VHL细胞中的IC50分别是0.625 μM和16 μM。 |
| 备注 | STF-62247 shows selectivtoxicity and growth inhibition of renal cells lacking VHL; 25-fold greater sensitivity observed for cells with VHL deficiency compared to wild-type (VHL+). |
| 生化机理 | Autophagy Inducer, STF-62247 is a small molecule agonist that induces autophagy and selectively causes lethality in renal cell carcinoma (RCC) cells that have lost the von Hippel-Lindau (VHL) tumor suppressor activity (IC50 = 625 nM). It significantly reduces the growth rate of tumors formed from VHL-deficient cells in mice. STF-62247 induces cytotoxicity in VHL-positive RCC cells only at higher concentrations (IC50 = 16 μM). Selectively induces non-apoptotic cell death in VHL- (von Hippel-Lindau) deficient, but not VHL-expressing, renal carcinoma cells both in vitro (IC50 = 0.625 and 16 μM in RCC4 and RCC4/VHL killing, respectively) and in mice. Although STF-62247 induces autophagy regardless of cellular VHL-expression level, STF-62247 treatment is shown to result in more enhanced/acidified autolysomes formation in VHL-deficient cells, implicating an important role of VHL in maintaining normal vesicular trafficking between ER, TNG, and lysosomes. |
| 别名 | STF62247;STF 62247;N-(3-甲基苯基)-4-(4-吡啶基)-1,3-噻唑-2-胺;STF62247;STF 62247;N-(3-Methylphenyl)-4-(4-pyridinyl)-2-thiazolamine |
STF-62247信息由上海阿拉丁生化科技股份有限公司为您提供，如您想了解更多关于STF-62247报价、型号、参数等信息，欢迎来电或留言咨询。
注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途