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其他小分子
PF-670462
| 品牌 | 厂商性质 | 产地 | 货期 |
|---|---|---|---|
| 阿拉丁 | 生产商 | 上海 | 现货 |
产品参数
| 货号 | CAS号 | 操作 |
|---|---|---|
| P127947-50mg | 950912-80-8 | 询价 |
| P127947-10mg | 950912-80-8 | 询价 |
产品介绍
- 分子式 C19H20FN5·2HCl
- 分子量410.32
属性
| 敏感性 | 对湿度敏感 |
| 溶解性 | Soluble in water (100 mM), and DMSO (100 mM). |
| 存贮条件 | 储存温度 2-8°C |
描述
| 应用 | A selective CK1ε and CK1δ inhibitor. |
| 产品介绍 | PF 670462 is a selective casein kinase, CK1ε and CK1δ inhibitor which also shows potency against 42 other kinases. In addition, PF 670462 can inhibit Period circadian protein homolog 1 (PER1) protein nuclear translocation which results in phase shifts in circadian rhythms. |
| 生化机理 | PF-670462 is a selective inhibitor of the δ- and ε-isoforms of casein kinase I, with IC50 values of 7.7 and 14 nM respectively, and >30 selectivity relative to 42 other kinases tested. Casein kinase Iε phosphorylates PER proteins, which are involved in setting the period of the circadian pacemaker or clock. PF-670462 is potent (IC50 7.7 nM) and effective in vivo (i.e. it induces profound phase delays in circadian periodicity). |
| 别名 | PF 670462;PF670462; 4-[1-环己基-4-(4-氟苯基)-1H-咪唑-5-基]-2-嘧啶胺盐酸盐;PF 670462;PF670462;4-[3-Cyclohexyl-5-(4-fluoro-phenyl)-3H-imidazol-4-yl]-pyrimidin-2-ylamine dihydrochloride;4-[1-Cyclohexyl-4-(4-fluorophenyl)-1H-imidazol-5-yl]-2-pyrimidinamine hydrochloride |
PF-670462信息由上海阿拉丁生化科技股份有限公司为您提供，如您想了解更多关于PF-670462报价、型号、参数等信息，欢迎来电或留言咨询。
注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途