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Nifuroxazide
| 品牌 | 厂商性质 | 产地 | 货期 |
|---|---|---|---|
| 阿拉丁 | 生产商 | 上海 | 现货 |
产品参数
| 货号 | CAS号 | 操作 |
|---|---|---|
| N129550-100mg | 965-52-6 | 询底价 |
| N129550-500mg | 965-52-6 | 询底价 |
| N129550-5g | 965-52-6 | 询底价 |
产品介绍
属性
| 熔点 | 281-283 °C |
| 溶解性 | Soluble in water (practically insoluble), chloroform (practically insoluble), ethyl ether (0.01g/>100ml) (practically insoluble), Methanol (0.01g/100ml) (very slightly soluble), 1 N Sodium hydroxide (1.0g/30ml), and DMSO. |
| 存贮条件 | 储存温度 2-8°C |
描述
| 应用 | An inhibitor of STAT activation and signaling activity |
| 生化机理 | Nifuroxazide is a nitrofuran compound inhibitor of STAT transcription factor signaling. Nifuroxazide is described to block constitutive phosphorylation of STAT3 by reducing Jak kinase autophosphorylation, decreasing the viability of myeloma cells depending on constitutive STAT3 activity for survival while not affecting normal peripheral blood mononuclear cells. Nifuroxazide produces decreases in tyrosine phosphorylation of Jak2 and Tyk2, and showed no effects on EGF receptor tyrosine kinase or Src kinase, indicating a relative specificity of Nifuroxazide for Jak2 and Tyk2. Nifuroxazide shows no inhibition of Akt or MAPK phosphorylation. |
| 别名 | 硝呋齐特;硝呋酚酰肼;4-羟基-2'-(5-硝基呋喃甲叉)-苯酰肼;5-Nitro-2-furaldehyde p-hydroxybenzoylhydrazone;p-Hydroxybenzoic acid (5-nitrofurfurylidene) hydrazide |
Nifuroxazide信息由上海阿拉丁生化科技股份有限公司为您提供，如您想了解更多关于Nifuroxazide报价、型号、参数等信息，欢迎来电或留言咨询。
注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途