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Montelukast sodium hydrate
| 品牌 | 厂商性质 | 产地 | 货期 |
|---|---|---|---|
| 阿拉丁 | 生产商 | 上海 | 现货 |
产品参数
| 货号 | CAS号 | 操作 |
|---|---|---|
| M129586-1g | 151767-02-1,158966-92-8 | 询价 |
| M129586-200mg | 151767-02-1,158966-92-8 | 询价 |
| M129586-5g | 151767-02-1,158966-92-8 | 询价 |
产品介绍
- 分子式 C35H35ClNO3S·Na · xH2O
- 分子量608.17 (anhydrous basis)
- Beilstein号
- EC号
- MDL号 MFCD00931431
- PubChem编号
属性
| 旋光率 | +95.0 to +105.0 deg(C=1、MeOH) |
| 敏感性 | 对湿度敏感;对空气敏感;对光线敏感 |
| 溶解性 |
|
| 存贮条件 | 储存温度2-8℃ |
描述
| 应用 | Montelukast sodium hydrate is a leukotriene receptor antagonist (LTRA) used for the maintenance treatment of asthma and to relieve symptoms of seasonal allergies. It is a subtype specific CysLT1 receptor antagonist. |
| 备注 | Montelukast selectively antagonizes leukotriene D 4 (LTD4) by binding to it so that block the action of leukotriene D4 on the cysteinyl leukotriene receptor CysLT1. |
| 生化机理 |
Montelukast Sodium(Singulair) is a potent, selective, anti-inflammatory CysLT1 receptor antagonist (IC50 < 5nM) with no appreciable affect on the CysLT2 receptor. In rat colitis Montelukast Sodium (Singulair) has demonstrated the ability to increase PGE2 production and lower COX-2 expression. Inhibition is competitive with respect to leukotrienes - particularly LTD4, a biologically active mediator that plays an important role in the control of several biochemical pathways involving pulmonary and immune system function. |
| 别名 | 孟鲁司特钠 水合物;1-[[[(1R)-1-[3-[(1E)-2-(7-Chloro-2-quinolinyl)ethenyl]phenyl]-3-[2-(1-hydroxy-1-methylethyl)phenyl]propyl]thio]methyl]cyclopropaneacetic acid sodium salt hydrate |
Montelukast sodium hydrate信息由上海阿拉丁生化科技股份有限公司为您提供，如您想了解更多关于Montelukast sodium hydrate报价、型号、参数等信息，欢迎来电或留言咨询。
注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途