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ABC294640
| 品牌 | 厂商性质 | 产地 | 货期 |
|---|---|---|---|
| 阿拉丁 | 生产商 | 上海 | 现货 |
| 货号 | CAS号 | 操作 |
|---|---|---|
| A127517-10mg | 915385-81-8 | 询价 |
| A127517-1mg | 915385-81-8 | 询价 |
| A127517-50mg | 915385-81-8 | 询价 |
| A127517-5mg | 915385-81-8 | 询价 |
属性
| 溶解性 | DMSO |
| 存贮条件 | 储存温度-20°C |
描述
| 生化机理 |
ABC294640 is an orally available, aryladamantane compound and selective inhibitor of sphingosine kinase-2 (SK2) with potential antineoplastic activity. Upon administration, ABC294640 competitively binds to and inhibits SK2, thereby preventing the phosphorylation of the pro-apoptotic amino alcohol sphingosine to sphingosine 1-phosphate (S1P), the lipid mediator that is pro-survival and critical for immunomodulation. This may eventually lead to the induction of apoptosis and may result in an inhibition of cell proliferation in cancer cells overexpressing SK2. SK2 and its isoenzyme SK1 are overexpressed in numerous cancer cell types. |
| 别名 | ; |
ABC294640信息由上海阿拉丁生化科技股份有限公司为您提供，如您想了解更多关于ABC294640报价、型号、参数等信息，欢迎来电或留言咨询。
注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途