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阿米洛利盐酸盐水合物
| 品牌 | 厂商性质 | 产地 | 货期 |
|---|---|---|---|
| 阿拉丁 | 生产商 | 上海 | 现货 |
产品参数
| 货号 | CAS号 | 操作 |
|---|---|---|
| A131615-1g | 2016-88-8 | 询底价 |
| A131615-5g | 2016-88-8 | 询底价 |
产品介绍
属性
| 溶解性 | Soluble in DMSO (25 mg/ml), water (10 mM warm), and methanol. Insoluble in chloroform, and ethanol. |
| 存贮条件 | 储存温度-20°C |
描述
| 应用 | A calcium channel andsodium channel protein inhibitor |
| 产品介绍 | Amiloride ? HCl is a selective T-type calcium channel protein inhibitor that has been shown to inhibit the Polycystin-L channel (Polycystic kidney disease 2-like 1 protein: PKD2L1), a member of the transient receptor potential (TRP) superfamily of cation channels, including the NHE (sodium/hydgrogen exchanger). Amiloride is also an epithelial sodium channel protein inhibitor, which inhibits sodium reabsorption without affecting potassium concentrations. Amiloride serves as a non-selective acid-sensing ion channel (ASIC) blocker and a selective inhibitor of uPA (urokinase plasminogen activator). Research shows that amiloride reduces electrical potential across tubular epithelium, inhibits angiogenesis and inhibits capillary morphogenesis completely and reversibly at approximately 130 μM. Amiloride ? HCl is an inhibitor of Sodium/Potassium-ATPase Protein. |
| 备注 | Amiloride hydrochloride(Midamor), a pyrazine compound inhibiting sodium reabsorption through sodium channels in renal epithelial cells. |
| 生化机理 | Selective T-type calcium channel blocker and blocker of epithelial sodium channel. Selective inhibitor of urokinase plasminogen activator (uPA). |
| 别名 | 盐酸阿米洛利;N-脒基-3,5-二氨基-6-氯吡嗪甲酰胺盐酸盐Midamor, Colectril, Amipramizide, Guanamprazine hydrochloride;1-(3,5-diamino-2-chloropyrazine-6-carbonyl)guanidine hydrochloride |
阿米洛利盐酸盐水合物信息由上海阿拉丁生化科技股份有限公司为您提供，如您想了解更多关于阿米洛利盐酸盐水合物报价、型号、参数等信息，欢迎来电或留言咨询。
注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途