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LY294002
| 品牌 | 厂商性质 | 产地 | 货期 |
|---|---|---|---|
| 阿拉丁 | 生产商 | 上海 | 现货 |
产品参数
| 货号 | CAS号 | 操作 |
|---|---|---|
| L124970-10mg | 154447-36-6 | 询价 |
| L124970-50mg | 154447-36-6 | 询价 |
| L124970-25mg | 154447-36-6 | 询价 |
产品介绍
- 分子式 C19H17NO3
- 分子量307.35
属性
| 溶解性 | Soluble in DMSO (25 mg/ml warm), ethanol (25 mg/ml warm), chloroform, water (< 50 ug/ml) at 25 °C, PBS pH 7.2 (< 50 ug/ml), DMF (~16 mg/ml ), and DMSO:PBS(1:1, pH 7.2) (~0.5 mg/ml ). |
| 存贮条件 | 储存温度2-8℃ |
描述
| 应用 | A potent blocker of PI 3-kinase/Akt signaling. |
| 产品介绍 | LY294002是第一个人工合成的PI3Kα/δ/β的抑制剂，IC50分别为0.5 μM/0.57 μM/0.97 μM，在溶液中比在Wortmannin中稳定，也能够抑制自噬体的形成。 |
| 备注 | LY294002 is the first synthetic molecule known to inhibit PI3Kα/δ/β with IC50 of 0.5 μM/0.57 μM/0.97 μM, respectively; more stable in solution than Wortmannin, and also blocks autophagosome formation. |
| 生化机理 | LY294002 is a potent inhibitor of PI 3-kinase, a protein in the phosphoinositide 3-kinase family of intercellular signal regulating enzymes. This compound is selective for PI 3-kinase p110 β (PI 3-Kβ) and PI 3-kinase p110 α (PI 3-Kα), although it will inhibit other PI 3 kinases at higher concentrations (IC50 = 310 nM and 730 nM for PI 3-Kβ and PI 3-Kα, respectively). The pathway associated with these receptors is implicated in cancer and diabetes, and LY294002 is an important tool for studying this relationship. Reports indicate that LY294002 encourages apoptosis in such cells by blocking the PI 3-kinase/Akt signaling pathway which has been strongly related to cancer survival and proliferation. LY 294002 is an inhibitor of Pim-1, PI 3-kinase p110 δ and PI 3-kinase p110 γ. |
| 别名 | 8-苯基-2-(吗啉-4-基)色原酮; 2-(4-吗啉基)-8-苯基-4H-1-苯并吡喃-4-酮;2-吗啉代-8-苯基-4-氧代-4H-1-苯并吡喃;NSC 697286; SF 1101; LY 294002; LY-294002;8-Phenyl-2-(morpholin-4-yl)chromen-4-one; 2-(4-Morpholinyl)-8-phenyl-4H-1-benzopyran-4-one;2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one;2-Morpholino-8-phenyl-4-oxo-4H-1-benzopyran |
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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途