诚信认证：
工商注册信息已核实！
快速导航
产品分类
微信二维码
Minisite
QQ号咨询
细胞信号转导
Dorsomorphin 2HCl
| 品牌 | 厂商性质 | 产地 | 货期 |
|---|---|---|---|
| 阿拉丁 | 生产商 | 上海 | 现货 |
产品参数
| 货号 | CAS号 | 操作 |
|---|---|---|
| D129758-50mg | 1219168-18-9 | 询价 |
| D129758-5mg | 1219168-18-9 | 询价 |
| D129758-10mg | 1219168-18-9 | 询价 |
产品介绍
属性
| 溶解性 | Soluble in water (100 mM), and DMSO (20 mM). |
| 存贮条件 | 储存温度-20°C |
描述
| 应用 | A potent and selective AMPK inhibitor. |
| 产品介绍 | Dorsomorphin 2HCl是一种有效的，可逆的AMPK选择性抑制剂，Ki为109 nM，对一些结构相关的激酶，包括ZAPK， SYK， PKCθ， PKA和JAK3没有显著的抑制作用。同时抑制了BMP一型受体作用。 |
| 备注 | Dorsomorphin is a potent, reversible, selective AMPK inhibitor with Ki of 109 nM, exhibiting no significant inhibition of several structurally related kinases including ZAPK, SYK, PKCθ, PKA, and JAK3. |
| 生化机理 | Dorsomorphin dihydrochloride has been shown to act as a potent and selective inhibitor of AMP-activated protein kinase (AMPK; Ki = 109 nM), induced by AICAR and metformin. Dorsomorphin dihydrochloride also inhibits the bone morphogenetic protein type 1 receptors ACTR-I (ALK2), BMPR-IA (ALK3), and BMPR-IB (ALK 6). This compound is not thought to show significant activity on structurally related kinases. Dorsomorphin, Free Base, is also available . |
| 别名 | BML-275;6-[4-[2-(1-哌啶基)乙氧基]苯基]-3-(4-吡啶基)吡唑并[1,5-a]嘧啶二盐酸盐;BML-275;6-[4-[2-(1-Piperidinyl)ethoxy]phenyl]-3-(4-pyridinyl)pyrazolo[1,5-a]pyrimidine hydrochloride (1:2);Compound C dihydrochloride; BML275 dihydrochloride; BML 275 dihydrochloride |
Dorsomorphin 2HCl信息由上海阿拉丁生化科技股份有限公司为您提供，如您想了解更多关于Dorsomorphin 2HCl报价、型号、参数等信息，欢迎来电或留言咨询。
注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途