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WYE-687
品牌 | 厂商性质 | 产地 | 货期 |
---|---|---|---|
阿拉丁 | 生产商 | 上海 | 现货 |
货号 | CAS号 | 操作 |
---|---|---|
W126399-1mg | 1062161-90-3 | 询价 |
W126399-25mg | 1062161-90-3 | 询价 |
W126399-50mg | 1062161-90-3 | 询价 |
W126399-5mg | 1062161-90-3 | 询价 |
属性
溶解性 |
|
存贮条件 | 储存温度-20°C |
描述
应用 | A potent ATP-competitive mTOR inhibitor with an IC50 of 7 nM |
产品介绍 | WYE-687是ATP竞争性mTOR选择性抑制剂,比对PI3Kα/γ的抑制性高超过100倍。 |
生化机理 |
WYE-687 is a potent ATP-competitive mTOR inhibitor with an IC50 of 7 nM. It is well reported that the mammalian target WYE-687 is a potent ATP-competitive mTOR inhibitor with an IC50 of 7 nM. It is well reported that the mammalian target of rapamycin (mTOR) is centrally involved in cell growth, metabolism, and angiogenesis. Significantly, the pyrazolopyrimidines were selective for mTOR over PI3Kα (>100-fold) and PI3Kγ (>500-fold) and were poorly active in a panel of 24 protein kinases. Unlike the rapalogs, WYE-687 acutely blocked mTORC2-dependent phosphorylation of AKT in vitro and in vivo. In various cancer cells, WYE-687 inhibited the mTORC1 substrate P-S6K(T389) and mTORC2 substrate P-AKT(S473) at submicromolar concentrations without significant inhibition of P-AKT(T308). WYE-687 was identified as an ATP-competitive, and selective inhibitor of mTOR kinase activity. |
别名 | WYE 687;WYE687; N-[4-[4-(4-吗啉基)-1-[1-(3-吡啶甲基)-4-哌啶基]-1H-吡唑并[3,4-d]嘧啶-6-基]苯基]氨基甲酸甲酯;WYE 687;WYE687;N-[4-[4-(4-Morpholinyl)-1-[1-(3-pyridinylmethyl)-4-piperidinyl]-1H-pyrazolo[3,4-d]pyrimidin-6-yl]phenyl]carbamic acid methyl ester |
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注:该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案,不可用于临床诊断或治疗等相关用途