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WAY-600

品牌 厂商性质 产地 货期
阿拉丁 生产商 上海 现货

询价
产品参数
货号 CAS号 操作
W129657-5mg 1062159-35-6 询价
W129657-25mg 1062159-35-6 询价
W129657-50mg 1062159-35-6 询价
产品介绍

  • 分子式 C28H30N8O
  • 分子量494.59

属性

溶解性
  • DMSO 22 mg/mL
  • Water <1 mg/mL
  • Ethanol 2 mg/mL
    • 存贮条件 储存温度-20°C

    描述

    应用 An ATP-competetive mTOR (FRAP) inhibitor
    产品介绍 WAY-600 is a potent, ATP-competitive and selective inhibitor of mTOR with IC50 of 9 nM; blocks mTORC1/P-S6K(T389) and mTORC2/P-AKT(S473) but not P-AKT(T308); selective for mTOR than PI3Kα (>100-fold) and PI3Kγ (>500-fold).
    生化机理 WAY-600 is a potent ATP-competitive mTOR inhibitor with an IC50 of about 9 nM. It is well reported that the mammalian target of rapamycin (sc-3504) (mTOR also known as FRAP) is centrally involved in cell growth, metabolism, and angiogenesis. WAY-600 has significant selectivity against mTOR (FRAP) over phosphatidylinositol 3-kinase (PI3K) isofoms (>100-fold). WAY-600 treated HEK293 cells indicated a 50% inhibition of polysomes by Way-600 compared with the 11% suppression by rapamycin. Unlike the rapalogs,WAY-600 acutely blocked mTORC2-dependent phosphorylation of AKT in vitro. In various cancer cells, WAY-600 inhibited the mTORC1 substrate P-S6K(T389) and mTORC2 substrate P-AKT(S473) at submicromolar concentrations without significant inhibition of P-AKT(T308).
    别名 WAY 600；6-(1H-吲哚-5-基)-4-(4-吗啉基)-1-[1-(3-吡啶基甲基)-4-哌啶基]-1H-吡唑并[3,4-d]嘧啶;WAY 600；6-(1H-Indol-5-yl)-4-(4-morpholinyl)-1-[1-(3-pyridinylmethyl)-4-piperidinyl]-1H-pyrazolo[3,4-d]pyrimidine

    WAY-600信息由上海阿拉丁生化科技股份有限公司为您提供，如您想了解更多关于WAY-600报价、型号、参数等信息，欢迎来电或留言咨询。

    注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途