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WYE-125132 (WYE-132)
品牌 | 厂商性质 | 产地 | 货期 |
---|---|---|---|
阿拉丁 | 生产商 | 上海 | 现货 |
产品参数
货号 | CAS号 | 操作 |
---|---|---|
W128041-100mg | 1144068-46-1 | 询价 |
W128041-25mg | 1144068-46-1 | 询价 |
W128041-5mg | 1144068-46-1 | 询价 |
产品介绍
- 分子式 C27H33N7O4
- 分子量519.61
属性
溶解性 |
|
存贮条件 | 储存温度-20°C |
密度 | 1.6000 |
描述
应用 | A highly potent, ATP-competitive, and specific mTOR kinase inhibitor |
产品介绍 | WYE-125132是ATP竞争性mTOR选择性抑制剂,IC50为0.19 nM,对PI3Ks及其相关的hSMG1和ATR抑制性较弱。 |
生化机理 | WYE-125132 is a potent, ATP-competitive inhibitor of recombinant mTOR kinase,with an IC50 of 0.19 nM. WYE-125132 shows an anti-proliferative activity against a variety of tumor cell lines with IC50 ranging from 2 nM (LNCap) to 380 nM (HTC116), in vitro. WYE-125132 causes inhibition of protein synthesis and cell size, induction of apoptosis, and cell cycle progression. WYE-125132 causes pre-tRNA Leu synthesis reduction by 72%, 80%, and 53% in actively proliferating cells of MG63, MDA361, and HEK293, respectively as a result of the inhibition of mTORC1. WYE-125132 induces Maf1 dephosphorylation and its accumulation in the nucleus. |
别名 | WYE-125132;WYE 125132; WYE125132;WYE 125132; N-[4-[1-(1,4-二氧杂螺[4.5]癸烷-8-基)-4-(8-氧杂-3-氮杂双环[3.2.1]辛烷-3-基)-1H-吡唑并[3,4-d]嘧啶-6-基]苯基]-N'-甲基脲;WYE-125132;WYE 125132;WYE125132;N-[4-[1-(1,4-Dioxaspiro[4.5]dec-8-yl)-4-(8-oxa-3-azabicyclo[3.2.1]oct-3-yl)-1H-pyrazolo[3,4-d]pyrimidin-6-yl]phenyl]-N'-methylurea |
WYE-125132 (WYE-132)信息由上海阿拉丁生化科技股份有限公司为您提供,如您想了解更多关于WYE-125132 (WYE-132)报价、型号、参数等信息,欢迎来电或留言咨询。
注:该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案,不可用于临床诊断或治疗等相关用途