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WYE-354
| 品牌 | 厂商性质 | 产地 | 货期 |
|---|---|---|---|
| 阿拉丁 | 生产商 | 上海 | 现货 |
产品参数
| 货号 | CAS号 | 操作 |
|---|---|---|
| W128007-5mg | 1062169-56-5 | 询价 |
| W128007-100mg | 1062169-56-5 | 询价 |
| W128007-25mg | 1062169-56-5 | 询价 |
产品介绍
- 分子式 C24H29N7O5
- 分子量495.54
属性
| 沸点 | ~594.2 °C at 760 mmHg |
| 折光率 | ~1.69 |
| 溶解性 | DMSO ≥96mg/mL Water <1.2mg/mL Ethanol <1.2mg/mL |
| 存贮条件 | 储存温度-20°C |
| 密度 | 1.5000 |
描述
| 应用 | A potent, specific, and ATP-competitive inhibitor to mTOR with IC50 of 5 nM |
| 产品介绍 | WYE-354是ATP竞争性mTOR抑制剂，IC50为5 nM，能阻断mTORC1/P-S6K(T389)和mTORC2/P-AKT(S473)，比对PI3Kα和PI3Kγ的抑制性强100倍和500倍。 |
| 生化机理 | WYE-354 is an inhibitor of several PI3Ks at micromolar levels. WYE-354 is an effective inhibitor of both mTORC1 and mTORC2 in HEK293 cells. WYE-354 significantly blocks mTOR signaling and Akt activation in U87MG and MDA361 cells. WYE-354 is a potent inhibitor of proliferation in tumor cell lines including MDA-MB-361, MDA-MB-231, MDA-MB-468, LNCap, A498, and HCT116. WYE-354 induces apoptosis which is accompanied by G1 cell cycle arrest and caspases activation. WYE-354 inhibits both mTORC1 and mTORC2 signaling, as revealed by dephosphorylation of S6 ribosomal protein and Akt, respectively, in endothelial HUVEC cells. WYE-354 activates mitogen-activated protein kinase (MAPK) signaling, which may be due to its inhibition of mTORC1. |
| 别名 | WYE 354; WYE354；4-[6-[4-[(甲氧羰基)氨基]苯基]-4-(4-吗啉基)-1H-吡唑并[3,4-d]嘧啶-1-基]-1-哌啶羧酸甲酯;WYE 354;WYE354； 4-[6-[4-[(Methoxycarbonyl)amino]phenyl]-4-(4-morpholinyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]-1-piperidinecarboxylic acid methyl ester |
WYE-354信息由上海阿拉丁生化科技股份有限公司为您提供，如您想了解更多关于WYE-354报价、型号、参数等信息，欢迎来电或留言咨询。
注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途