诚信认证：
工商注册信息已核实！
快速导航
产品分类
微信二维码
Minisite
QQ号咨询
细胞信号转导
TIC10 Analogue
| 品牌 | 厂商性质 | 产地 | 货期 |
|---|---|---|---|
| 阿拉丁 | 生产商 | 上海 | 现货 |
产品参数
| 货号 | CAS号 | 操作 |
|---|---|---|
| T129707-5mg | 41276-02-2 | 询价 |
| T129707-100mg | 41276-02-2 | 询价 |
| T129707-25mg | 41276-02-2 | 询价 |
产品介绍
- 分子式 C24H26N4O
- 分子量386.49
属性
| 溶解性 |
|
| 存贮条件 | 储存温度-20°C |
描述
| 应用 | A small molecule that induces TRAIL in a p53-independent manner |
| 产品介绍 | TIC10(ONC201 isomer)是口服活性的稳定化合物，能抑制Akt和ERK，能透过血脑屏障，可诱导TRAIL。 |
| 备注 | TIC10 inactivates Akt and ERK to induce TRAIL through Foxo3a, possesses superior drug properties: delivery across the blood-brain barrier, superior stability and improved pharmacokinetics. |
| 生化机理 | TIC10 (TRAIL-inducing compound 10) is an orally active, stable and potent small molecule that has been shown to transcriptionally induce TRAIL and TRAIL-mediated cell death in a p53-independent manner. TIC10 also activates the gene Foxo3a by dually inactivating Akt and ERK. TIC10 crosses the blood-brain barrier and is expected to be useful as an antitumor therapeutic agent. |
| 别名 | ONC201, NSC 350625;2,6,7,8,9,10-六氢-10-[(2-甲基苯基)甲基]-7-(苯基甲基)咪唑并[1,2-a]吡啶并[4,3-d]嘧啶-5(3H)-酮;TRAIL-inducing Compound 10;TIC10 isomer; ONC201 isomer;2,6,7,8,9,10-Hexahydro-10-[(2-methylphenyl)methyl]-7-(phenylmethyl)imidazo[1,2-a]pyrido[4,3-d]pyrimidin-5(3H)-one |
TIC10 Analogue信息由上海阿拉丁生化科技股份有限公司为您提供，如您想了解更多关于TIC10 Analogue报价、型号、参数等信息，欢迎来电或留言咨询。
注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途