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TBB
| 品牌 | 厂商性质 | 产地 | 货期 |
|---|---|---|---|
| 阿拉丁 | 生产商 | 上海 | 现货 |
产品参数
| 货号 | CAS号 | 操作 |
|---|---|---|
| T125016-10mg | 17374-26-4 | 询价 |
| T125016-1g | 17374-26-4 | 询价 |
| T125016-50mg | 17374-26-4 | 询价 |
| T125016-5g | 17374-26-4 | 询价 |
产品介绍
- 分子式 C6HBr4N3
- 分子量434.71
- MDL号 MFCD06411399
- PubChem编号 24724628
属性
| 溶解性 | Soluble in DMSO (100 mM), ethanol (20 mM), DMF (~20 mg/ml), and 1:1 solution of DMF:PBS (pH7.2, ~0.5 mg/ml). |
| 存贮条件 | 储存温度 2-8°C |
描述
| 应用 | A highly selective CK2α, Dyrk1A, and NS3 viral helicase inhibitor. |
| 产品介绍 | TBB(NSC 231634)是ATP/GTP竞争性CK2抑制剂，对鼠肝和人重组CK2的IC50分别为0.9和1.6 μM。 |
| 生化机理 | TBB is a cell-permeable benzotriazolo compound that acts as a highly selective ATP/GTP-competitive protein kinase inhibitor. It has been shown to specifically inhibit casein kinase IIα (CK2α) and dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A (Dyrk1A). TBB’s strong binding action appears to result from both hydrophobic and van der Walls interactions. Other kinases such as GSK (glycogen synthase kinase), Cdk2 (CDK2) and phosphorylase kinase were inhibited to a lesser extent. TBB has also been shown to inhibit NS3-associated viral helicase activities in hepatitis C virus and West Nile virus. TBB has been used as an apoptotic inducer in Jerkat cells. |
| 别名 | 4,5,6,7-四溴苯并三唑;NSC 231634; TBB (enzyme inhibitor);1H-Benzotriazole;4,5,6,7-Tetrabromobenzotriazole; 4,5,6,7-Tetrabromo-2-azabenzimidazole; TBBt |
TBB信息由上海阿拉丁生化科技股份有限公司为您提供，如您想了解更多关于TBB报价、型号、参数等信息，欢迎来电或留言咨询。
注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途