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TG100-115
品牌 | 厂商性质 | 产地 | 货期 |
---|---|---|---|
阿拉丁 | 生产商 | 上海 | 现货 |
产品参数
货号 | CAS号 | 操作 |
---|---|---|
T127783-100mg | 677297-51-7 | 询价 |
T127783-1mg | 677297-51-7 | 询价 |
T127783-25mg | 677297-51-7 | 询价 |
T127783-5mg | 677297-51-7 | 询价 |
产品介绍
属性
溶解性 |
|
存贮条件 | 储存温度-20°C |
描述
应用 | A PI3K and FRAP inhibitor with some action against Akt |
产品介绍 | TG100-115是PI3K γ和δ抑制剂,IC50分别为83和235 nM。 |
备注 | TG100115 is a PI3Kγ/δ inhibitor with IC50 of 83 nM/235 nM, with little effect on PI3Kα/β. Phase 1/2. |
生化机理 | TG100-115 inhibits PI 3-kinase p110 γ and PI 3-kinase p110 δ (PI3Kγ and -δ), with IC50 of 83 and 235 nM, respectively. TG100-115 is not active for PI3Kα and -β, with IC50 of 1.2 and 1.3 mM. TG100-115 (10 μM) interrupts other VEGF signaling pathways, such as those that culminate in VE-cadherin phosphorylation. In HUVECs, TG100-115 (10 μM) inhibits the VEGF-induced increase of total level of VE-cadherin. TG100-115 inhibits VEGF mediated phosphorylation of mTOR, also known as FRAP, and p70S6 kinase, both of which are downstream of PI3K. TG100-115 (125 nM to 10 μM) also inhibits FGF-stimulated phosphorylation of Akt. |
别名 | TG100115;TG100 115;3,3'-(2,4-二氨基-6,7-蝶啶二基)二苯酚;TG100115;TG100 115;3,3'-(2,4-Diamino-6,7-pteridinediyl)bisphenol;6,7-Bis(3-hydroxyphenyl)pteridine-2,4-diamine |
TG100-115信息由上海阿拉丁生化科技股份有限公司为您提供,如您想了解更多关于TG100-115报价、型号、参数等信息,欢迎来电或留言咨询。
注:该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案,不可用于临床诊断或治疗等相关用途