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Tideglusib
| 品牌 | 厂商性质 | 产地 | 货期 |
|---|---|---|---|
| 阿拉丁 | 生产商 | 上海 | 现货 |
产品参数
| 货号 | CAS号 | 操作 |
|---|---|---|
| T127039-25mg | 865854-05-3 | 询价 |
| T127039-5mg | 865854-05-3 | 询价 |
| T127039-100mg | 865854-05-3 | 询价 |
产品介绍
- 分子式 C19H14N2O2S
- 分子量334.39
- MDL号 MFCD18633296
属性
| 溶解性 |
|
| 存贮条件 | 储存温度-20°C |
描述
| 产品介绍 | Tideglusib(NP-031112)是不可逆的非ATP竞争性GSK-3β抑制剂，IC50为60 nM。 |
| 备注 | Tideglusib is an irreversible, non ATP-competitive GSK-3β inhibitor with IC50 of 60 nM; fails to inhibit kinases with a Cys homologous to Cys-199 located in the active site. Phase 1/2. |
| 生化机理 | Tideglusib, also known as NP031112 or NP-12, is a potent non ATP-competitive inhibitor of glycogen synthase kinase-3 (GSK3), an important kinase studied in stem cell research and neurodegenerative diseases. It is currently in clinical trials for Alzheimer′s disease and Progressive Supranuclear Palsy (PSP). Tideglusib reduces phosphorylation of the tau protein and the accumulation of amyloid plaques, reduces hippocampal and entorhinal cortex neuron loss and improves spatial memory deficits. It has also shown neuroprotective and anti-inflammatory activity in a variety of animal models. |
| 别名 | NP-12;NP031112;4-苄基-2-(萘-1-基)-[1,2,4]噻二唑烷-3,5-二酮;NP 031112;NP-031112;4-Benzyl-2-(naphthalen-1-yl)-[1,2,4]thiadiazolidine-3,5-dione |
Tideglusib信息由上海阿拉丁生化科技股份有限公司为您提供，如您想了解更多关于Tideglusib报价、型号、参数等信息，欢迎来电或留言咨询。
注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途