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细胞信号转导
SB415286
品牌 | 厂商性质 | 产地 | 货期 |
---|---|---|---|
阿拉丁 | 生产商 | 上海 | 现货 |
产品参数
货号 | CAS号 | 操作 |
---|---|---|
S129720-10mg | 264218-23-7 | 询价 |
S129720-1mg | 264218-23-7 | 询价 |
S129720-50mg | 264218-23-7 | 询价 |
产品介绍
- 分子式 C16H10ClN3O5
- 分子量359.72
- EC号 MFCD04039789
- MDL号 MFCD04039789
- PubChem编号 24278412
属性
溶解性 |
|
存贮条件 | 储存温度-20°C |
描述
产品介绍 | SB 415286 |
合法信息 | Sold for only research purposes |
备注 | SB415286 is a potent GSK3α inhibitor with IC50/Ki of 78 nM/31 nM with equally effective inhibition of GSK-3β. |
生化机理 |
SB 415286 is a potent and selective cell-permeable, ATP-competitive inhibitor of GSK3α with an IC50 value of 78 nM (similar potency for GSK3β) and a Ki value of 31 nM. 1 As a result of GSK3 inhibition, SB 415286 stimulates glycogen synthesis in the Chang human liver cell line with an EC50 value of 2.9 ?M. SB 415286 also protects primary neurons from death induced by the PI3-kinase pathway. |
别名 | 3-(3-chloro-4-hydroxyphenylamino)-4-(2-nitrophenyl)-1H-pyrrole-2,5-dione;3-(3-chloro-4-hydroxyphenylamino)-4-(2-nitrophenyl)-1H-pyrrole-2,5-dione |
SB415286信息由上海阿拉丁生化科技股份有限公司为您提供,如您想了解更多关于SB415286报价、型号、参数等信息,欢迎来电或留言咨询。
注:该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案,不可用于临床诊断或治疗等相关用途