诚信认证：
工商注册信息已核实！
快速导航
产品分类
微信二维码
Minisite
QQ号咨询
细胞信号转导
PI-103
| 品牌 | 厂商性质 | 产地 | 货期 |
|---|---|---|---|
| 阿拉丁 | 生产商 | 上海 | 现货 |
产品参数
| 货号 | CAS号 | 操作 |
|---|---|---|
| P125961-10mg | 371935-74-9 | 询价 |
| P125961-50mg | 371935-74-9 | 询价 |
| P125961-100mg | 371935-74-9 | 询价 |
产品介绍
- 分子式 C19H16N4O3
- 分子量348.36
属性
| 溶解性 | Soluble in DMSO (10 mg/ml), DMF (10 mg/ml), 1:2 DMSO:PBS(pH 7.2) (0.25 mg/ml), water (<1 mg/ml) at 25 °C, and ethanol (<1 mg/ml) at 25 °C. |
| 存贮条件 | 储存温度-20°C |
描述
| 应用 | An ATP-competitive DNA-PK, PI 3-kinase, and FRAP inhibitor. |
| 产品介绍 | PI-103是一种多靶点的PI3K抑制剂，对p110α的抑制效果最好，IC50为2 nM (对p110β/δ/γ抑制效果稍弱)，也抑制mTORC1/2和DNA-PK ，IC50分别为20 nM/83 nM和8 nM。 |
| 备注 | PI-103 is a multi-targeted PI3K inhibitor for p110α/β/δ/γ with IC50 of 2 nM/3 nM/3 nM/15 nM, less potent to mTOR/DNA-PK with IC50 of 30 nM/23 nM. |
| 生化机理 | PI-103 is a cell-permeable pyridinylfuranopyrimidine compound that acts as an ATP-competitive inhibitor of DNA-PK, PI 3-kinase (Class IA), and FRAP (mTOR) complex 1 and 2. Studies suggest that PI-103 can induce apoptosis and an arrest in the cell cycle by inhibition of the aforementioned proteins. When PI-103 is combined with rapamycin, a prototypic mTORC1 inhibitor, synergistic suppression of AKT and ribosomal S6 protein phosphorylation are observed. In addition, PI-103 has been seen to have nominal effects inhibiting basal Na+ transport, but is very effective in abolishing insulin-induced Na+ absorption in the nephron. |
| 别名 | PI 103 ; 3-[4-(4-吗啉基吡啶并[3',2',4,5]呋喃并[3,2-d]嘧啶-2-基]苯酚;PI 103;PI103;PI 3-K Inhibitor V;3-[4-(4-Morpholinylpyrido[3',2',4,5]furo[3,2-d]pyrimidin-2-yl]phenol |
PI-103信息由上海阿拉丁生化科技股份有限公司为您提供，如您想了解更多关于PI-103报价、型号、参数等信息，欢迎来电或留言咨询。
注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途