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OSU-03012 (AR-12)
| 品牌 | 厂商性质 | 产地 | 货期 |
|---|---|---|---|
| 阿拉丁 | 生产商 | 上海 | 现货 |
产品参数
| 货号 | CAS号 | 操作 |
|---|---|---|
| O126958-25mg | 742112-33-0 | 询价 |
| O126958-5mg | 742112-33-0 | 询价 |
| O126958-100mg | 742112-33-0 | 询价 |
产品介绍
- 分子式 C26H19F3N4O
- 分子量460.46
属性
| 熔点 | 177-180 °C |
| 溶解性 | Soluble in DMSO (11 mg/ml at 25 °C), water (<1 mg/ml at 25 °C), ethanol (<1 mg/ml at 25 °C), and 0.5% methylcellulose/0.2% Tween 80 (30 mg/ml at 25 °C). |
| 存贮条件 | 储存温度-20°C |
描述
| 应用 | A PDK1 inhibitor and inducer of caspase and p53-independent apoptosis. |
| 产品介绍 | OSU-03012 (AR-12)是一种有效的重组PDK-1抑制剂，IC50为5 μM，比OSU-02067作用效果高2倍。 |
| 备注 | OSU-03012 is a potent inhibitor of recombinant PDK-1 with IC50 of 5 μM and 2-fold increase in potency over OSU-02067. |
| 生化机理 | OSU 03012 is a potent inhibitor of PDK1 (IC50 = 5 μM). OSU 03012 causes a dose-dependent induction of cell death regardless of the presence or absence of mutated p53. Studies have shown that upon treatment of cells with OSU 03012 there is an accumulation of reactive oxygen species (ROS) in the cell, which may contribute to cell death through oxidative damage. Exposure to ionizing radiation following treatment with OSU 03012 causes an increase in cell death, which is also caspase-independent. |
| 别名 | 2-氨基-N-[4-[5-(2-菲基)-3-(三氟甲基)-1H-吡唑-1-基]苯基]乙酰胺;N/AAR-12; OSU03012; OSU 03012;2-Amino-N-[4-[5-(2-phenanthrenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]phenyl]acetamide |
OSU-03012 (AR-12)信息由上海阿拉丁生化科技股份有限公司为您提供，如您想了解更多关于OSU-03012 (AR-12)报价、型号、参数等信息，欢迎来电或留言咨询。
注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途