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MK-2206 2HCl
| 品牌 | 厂商性质 | 产地 | 货期 |
|---|---|---|---|
| 阿拉丁 | 生产商 | 上海 | 现货 |
产品参数
| 货号 | CAS号 | 操作 |
|---|---|---|
| M129684-10mg | 1032350-13-2 | 询底价 |
| M129684-50mg | 1032350-13-2 | 询底价 |
| M129684-100mg | 1032350-13-2 | 询底价 |
产品介绍
- 分子式 C25H21N5O·2HCl
- 分子量480.39
属性
| 熔点 | >225 °C |
| 溶解性 | Soluble in DMSO (≥92 mg/ml), water (≥92 mg/ml), ethanol (≥1.8 mg/ml), and methanol. |
| 存贮条件 | 储存温度-20°C |
描述
| 应用 | A highly selective pan-Akt inhibitor activated by the pleckstrin homology domain |
| 产品介绍 | MK-2206 2HCl是一种高度选择性的Akt1/2/3抑制剂，IC50分别为8 nM/12 nM/65 nM；对250种其他蛋白激酶没有抑制活性。 |
| 备注 | MK-2206 2HCl is a highly selective inhibitor of Akt1/2/3 with IC50 of 8 nM/12 nM/65 nM, respectively; no inhibitory activities against 250 other protein kinases observed. Phase 2. |
| 生化机理 | MK-2206 2HCl is a highly selective inhibitor of Akt1, Akt2, and Akt3 with IC50 values of 8 nM, 12 nM and 65 nM, respectively. MK-2206 is an allosteric inhibitor and is activated by the pleckstrin homology domain. MK-2206 inhibits auto-phosphorylation of both Akt T308 and S473. MK-2206 also prevents Akt-mediated phosphorylation of downstream signaling molecules, including TSC2, PRAS40 and ribosomal S6 proteins. MK-2206 also shows synergistic responses in combination with cytotoxic agents such as erlotinib or lapatinib in lung NCI-H460 or ovarian A2780 tumor cells |
| 别名 | MK2206; 8-[4-(1-氨基环丁基)苯基]-9-苯基-1,2,4-三唑并[3,4-f][1,6]萘啶-3(2H)-酮二盐酸盐;MK2206;MK-2206 dihydrochloride;8-[4-(1-Aminocyclobutyl)phenyl]-9-phenyl-1,2,4-triazolo[3,4-f][1,6]naphthyridin-3(2H)-one dihydrochloride |
MK-2206 2HCl信息由上海阿拉丁生化科技股份有限公司为您提供，如您想了解更多关于MK-2206 2HCl报价、型号、参数等信息，欢迎来电或留言咨询。
注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途