诚信认证:
工商注册信息已核实!
![](https://img.antpedia.com/cbook/dist_templates/0/images/icon04.png)
快速导航
产品分类
微信二维码
![](https://cbook.antpedia.com/attachments/design/6751/1577268752-5396.png)
Minisite
细胞信号转导
A-674563
品牌 | 厂商性质 | 产地 | 货期 |
---|---|---|---|
阿拉丁 | 生产商 | 上海 | 现货 |
产品参数
货号 | CAS号 | 操作 |
---|---|---|
A126845-25mg | 552325-73-2 | 询价 |
A126845-5mg | 552325-73-2 | 询价 |
A126845-100mg | 552325-73-2 | 询价 |
产品介绍
- 分子式 C22H22N4O
- 分子量358.44
属性
沸点 | ~624.4° C at 760 mmHg |
熔点 | 243.14° C |
折光率 | 1.66 |
溶解性 |
|
存贮条件 | 储存温度-20°C |
密度 | 1.2000 |
描述
应用 | A selective Akt1, PKA, and CDK2 inhibitor |
产品介绍 | A-674563是Akt1抑制剂,IC50为14 nM,还能抑制PKA和CDK2,IC50分别为16和46 nM。 |
备注 | A-674563 is an Akt1 inhibitor with Ki of 11 nM, modest potent to PKA and >30-fold selective for Akt1 over PKC. |
生化机理 | A-674563 is achieved from A-443654 by replacing the indole with a phenyl moiety and getting oral activity. A-674563 slows proliferation of tumor cells with EC50 of 0.4 μM. A-674563 does not inhibit Akt phosphorylation per se, but blocks the phosphorylation of Akt downstream targets in a dose-dependent manner. A-674563 induced Akt blockade results in decreased STS cell downstream target phosphorylation and tumor cell growth inhibiton. A-674563 induces G2 cell cycle arrest and apoptosis in STS cells. |
别名 | A 674563; A674563;(alphas)-alpha-(((5-(3-methyl-1h-indazol-5-yl)-3-pyridinyl)oxy)methyl)benzeneethanamine;(2s)-1-{[5-(3-Methyl-1h-Indazol-5-Yl)pyridin-3-Yl]oxy}-3-Phenylpropan-2-Amine;A 674563; A674563; (alphaS)-alpha-(((5-(3-甲基-1H-吲唑-5-基)-3-吡啶基)氧)甲基)苯乙胺; |
A-674563信息由上海阿拉丁生化科技股份有限公司为您提供,如您想了解更多关于A-674563报价、型号、参数等信息,欢迎来电或留言咨询。
注:该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案,不可用于临床诊断或治疗等相关用途