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Acadesine
| 品牌 | 厂商性质 | 产地 | 货期 |
|---|---|---|---|
| 阿拉丁 | 生产商 | 上海 | 现货 |
产品参数
| 货号 | CAS号 | 操作 |
|---|---|---|
| A129749-50mg | 2627-69-2 | 询价 |
| A129749-1g | 2627-69-2 | 询价 |
| A129749-250mg | 2627-69-2 | 询价 |
产品介绍
- 分子式 C9H14N4O5
- 分子量258.23
- Beilstein号
- EC号 220-097-5
- MDL号 MFCD00869751
- PubChem编号 24724407
属性
| 溶解性 | Soluble in water (9 mg/ml), and DMSO (75 mM). |
| 存贮条件 | 储存温度-20°C |
描述
| 应用 | An inhibitor of the transcription of PPARα, the coactivation of PPARα. |
| 产品介绍 | Acadesine导致ZMP的积累，Acadesine模仿AMP对AMPK和AMPK的刺激作用。 |
| 备注 | Acadesine results in accumulation of ZMP, which mimics the stimulating effect of AMP on AMPK and AMPK. Phase 3. |
| 生化机理 | AICAR (AICA-Riboside) strongly inhibits the transcription of PPAR&alpha and the coactivation of PPAR&alpha. In adipocyte studies it has been shown to antagonize lipolysis induced by isoprenaline and has been suggested for use in kinase cascade research. Additionally, research indicates that AICAR blocks the differentiation of 3T3-L1 (sc-2243) adipocytes. Studies demonstrate that AICAR can mimic the activity of insulin by activating AMPK (AMP-activated protein kinase), and affecting the expression of PEPCK-M (PEPCK) and glucose-6-phosphatase (G6Pase). The 5-aminoimidazole-4-carboxamide ribonucleoside (ZMP) is the monophosphorylated derivative of AICA-Riboside, and it can serve as the substrate for the aminoimidazole carboxamide ribonucleotide transformylase/inosine monophosphate cyclohydrolase (ATIC). AICAR is an inhibitor of Hsp90, mTOR and p70 S6 Kinase. |
| 别名 | 阿卡地新; 5-氨基-1-beta-D-呋喃核糖基-1H-咪唑-4-甲酰胺;AICAR;5-Amino-1-(β-D-ribofuranosyl)-1H-imidazole-4-carboxamide;5-Aminoimidazole-4-carboxamide ;1-β-D-ribofuranoside ; N1-(β-D-Ribofuranosyl)-5-aminoimidazole-4-carboxamide |
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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途