诚信认证：
工商注册信息已核实！
快速导航
产品分类
微信二维码
Minisite
QQ号咨询
蛋白酶
DAPT
| 品牌 | 厂商性质 | 产地 | 货期 |
|---|---|---|---|
| 阿拉丁 | 生产商 | 上海 | 现货 |
产品参数
| 货号 | CAS号 | 操作 |
|---|---|---|
| D126677-5mg | 208255-80-5 | 询价 |
| D126677-25mg | 208255-80-5 | 询价 |
| D126677-50mg | 208255-80-5 | 询价 |
| D126677-10mg | 208255-80-5 | 询价 |
产品介绍
- 分子式 C23H26F2N2O4
- 分子量432.46
- MDL号 MFCD04974585
- PubChem编号 24893987
属性
| 敏感性 | 对热敏感 |
| 溶解性 | Soluble in DMSO (15 mg/mL), ethanol (~1 mg/mL), dichloromethane, DMF (~25 mg/mL), and 1:9 solution of DMF:PBS(pH 7.2) (~0.1 mg/mL). |
| 存贮条件 | 储存温度2-8°C |
描述
| 应用 | A potent and specific inhibitor of γ-secretase. |
| 产品介绍 | DAPT (GSI-IX)是一种新型γ-分泌酶抑制剂，抑制HEK 293细胞中全部Aβ产量， IC50为20 nM。 |
| 备注 | DAPT (GSI-IX) is a novel γ-secretase inhibitor, which inhibits Aβ production with IC50 of 20 nM in HEK 293 cells. |
| 生化机理 | DAPT is a potent and specific inhibitor of γ-secretase. It has been shown to cause a reduction in Aβ40 and Aβ42 levels in human primary neuronal cultures (IC50 values are 115 and 200 nM for total Aβ40 and Aβ42 respectively). There is evidence that DAPT does not effect APPα and APPβ levels. It mimics notch signaling deficiencies at morphological, molecular and biochemical levels and has been shown to block notch signaling in hybrid human-mouse foetal thymus organ culture (FTOC). |
| 别名 | GSI-IX;(3,5-二氟苯乙酰基)-Ala-Phg-OtBu;(3,5-二氟苯乙酰基)-L-丙氨酰基-L-2-苯基甘氨酸叔丁酯;GSI-IX;GSI IX;γ-Secretase Inhibitor IX; LY-374973; N-[N-(3,5-Difluorophenacetyl)-L-alanyl]-S-phenylglycine t-butyl ester;(3,5-Difluorophenylacetyl)-L-alanyl-L-2-phenylglycine tert-Butyl Ester;(3,5-Difluorophenylacetyl)-Ala-Phg-OtBu |
DAPT信息由上海阿拉丁生化科技股份有限公司为您提供，如您想了解更多关于DAPT报价、型号、参数等信息，欢迎来电或留言咨询。
注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途