诚信认证：
工商注册信息已核实！
快速导航
产品分类
微信二维码
Minisite
QQ号咨询
蛋白酶
MG-132
| 品牌 | 厂商性质 | 产地 | 货期 |
|---|---|---|---|
| 阿拉丁 | 生产商 | 上海 | 现货 |
产品参数
| 货号 | CAS号 | 操作 |
|---|---|---|
| M126521-5mg | 133407-82-6 | 询底价 |
| M126521-100mg | 133407-82-6 | 询底价 |
| M126521-1g | 133407-82-6 | 询底价 |
| M126521-25mg | 133407-82-6 | 询底价 |
产品介绍
- 分子式 C26H41N3O5
- 分子量475.62
属性
| 溶解性 | Soluble in DMSO (25 mg/ml), 100% ethanol (25 mg/ml), chloroform:methanol solution (95:5) (10 mg/ml), water (<1 mg/ml), and DMF (~25 mg/ml). |
| 存贮条件 | 储存温度-20°C |
描述
| 应用 | A proteasome and NF-κB inhibitor. |
| 产品介绍 | MG-132是一种蛋白酶体抑制剂，IC50为100 nM，也抑制钙蛋白酶，IC50为1.2 μM。 |
| 备注 | MG-132 is an inhibitor of proteasome with IC50 of 100 nM, and also inhibits calpain with IC50 of 1.2 μM. |
| 生化机理 | MG-132 [Z-Leu-Leu-Leu-CHO] is a proteasome inhibitor, used as a tool for perturbing the proteasome-regulated degradation of intracellular proteins. These proteins processed by the proteasome are involved in inflammatory processes and cell cycle regulation, presenting broad relevance for aldehydic proteasome inhibitors of this type. MG-132 suppresses NF-κB activation (at 10 μM) by preventing IκB degradation (IC50=3 μM), which blocks the transcription factor from providing chemoresistance to cancer cells. It is also an an inhibitor of calpain. MG-132 [Z-Leu-Leu-Leu-CHO] is an inhibitor of 26S Proteasome and an activator of JNK1, c-Jun and c-Fos. |
| 别名 | MG132;蛋白酶体抑制剂; N-[(苄氧基)羰基]-L-亮氨酰-N-[(1S)-1-甲酰基-3-甲基丁基]-L-亮氨酰胺;Z-Leu-Leu-Leu-al;Carbobenzoxy-L-leucyl-L-leucyl-L-leucinal;Calpain inhibitor IV-2; N-[(Phenylmethoxy)carbonyl]-L-leucyl-N-[(1S)-1-formyl-3-methylbutyl]-L-leucinamide |
MG-132信息由上海阿拉丁生化科技股份有限公司为您提供，如您想了解更多关于MG-132报价、型号、参数等信息，欢迎来电或留言咨询。
注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途