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Capmatinib (INCB28060)
| 品牌 | 厂商性质 | 产地 | 货期 |
|---|---|---|---|
| 阿拉丁 | 生产商 | 上海 | 现货 |
产品参数
| 货号 | CAS号 | 操作 |
|---|---|---|
| I127200-50mg | 1029712-80-8 | 询价 |
| I127200-10mg | 1029712-80-8 | 询价 |
产品介绍
- 分子式 C23H17FN6O
- 分子量412.42
属性
| 溶解性 | 25°C: DMSO2mg/mL; Water <1 mg/mL; Ethanol <1 mg/mL |
| 存贮条件 | 储存温度-20°C |
描述
| 应用 | A novel inhibitor of Met (IC50 = 0.13 nM) |
| 产品介绍 | INCB28060是高活性c-MET口服活性抑制剂，IC50为0.13 nM。 |
| 备注 | INCB28060 is a novel, ATP-competitive inhibitor of c-MET with IC50 of 0.13 nM, inactive against RONβ, as well as EGFR and HER-3. Phase 1. |
| 生化机理 | INCB28060 exhibits picomolar enzymatic potency and is highly specific for c-MET with more than 10,000-fold selectivity over a large panel of human kinases. INCB28060 inhibits human c-MET phosphorylation and c-MET-mediated signaling in cancer cells. INCB28060 inhibits c-MET-dependent cell proliferation and survival, and prevents anchorage-independent cancer cell growth and cell migration. |
| 别名 | INCB-28060; INC-280；2-氟-N-甲基-4-(7-((喹啉-6-基)甲基)咪唑并(1,2-b)-(1,2,4)三嗪-2-基)苯甲酰胺;;Capmatinib; INCB-28060; INC-280;2-fluoro-N-methyl-4-(7-(quinolin-6-ylmethyl)imidazo[1,2-b][1,2,4]triazin-2- yl)benzamide |
Capmatinib (INCB28060)信息由上海阿拉丁生化科技股份有限公司为您提供，如您想了解更多关于Capmatinib (INCB28060)报价、型号、参数等信息，欢迎来电或留言咨询。
注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途