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Erlotinib HCl (OSI-744)
品牌 | 厂商性质 | 产地 | 货期 |
---|---|---|---|
阿拉丁 | 生产商 | 上海 | 现货 |
产品参数
货号 | CAS号 | 操作 |
---|---|---|
E129310-500mg | 183319-69-9 | 询价 |
E129310-5g | 183319-69-9 | 询价 |
E129310-100mg | 183319-69-9 | 询价 |
E129310-1g | 183319-69-9 | 询价 |
产品介绍
- 分子式 C22H23N3O4·HCl
- 分子量429.90
属性
溶解性 | Soluble in DMSO (3 mg/ml), methanol (sparingly), water (<1 mg/ml), and ethanol (<1 mg/ml). |
存贮条件 | 储存温度-20°C |
描述
应用 | A HER-1/EGFR tyrosine kinase inhibitor |
产品介绍 | Erlotinib HCl (OSI-744)是一种EGFR抑制剂,在无细胞试验中IC50为2 nM,对EGFR的选择性比对人c-Src或v-Abl高1000多倍。 |
备注 | Erlotinib HCl (OSI-744) is an EGFR inhibitor with IC50 of 2 nM, >1000-fold more sensitive for EGFR than human c-Src or v-Abl. Phase 3. |
生化机理 | Erlotinib Hydrochloride is a small molecule inhibitor of the EGFR/HER-1 (human epidermal growth factor receptor) tyrosine kinase. Overexpression of the EGFR is present in many carcinomas, and inhibition of the activating kinase by Erlotinib provides a chemical intervention upon these systems. The inhibition of this tyrosine kinase effectively blocks EGFR activity but does not suppress tumor growth. When combined with 3,3'-diindolylmethane, efficacy against tumor proliferation was demonstrated. |
别名 | 盐酸埃罗替尼; N-(3-乙炔苯基)-[6,7-二(2-甲氧基乙氧基)]喹唑啉-4-胺盐酸盐;Tarceva; CP-358774; OSI-774; NSC 718781;N-(3-Ethynylphenyl)[6,7-bis(2-methoxyethoxy)quinazolin-4-yl]amine hydrochloride; 6,7-Bis(2-methoxyethoxy)-4-(3-ethynylanilino)quinazoline hydrochloride |
Erlotinib HCl (OSI-744)信息由上海阿拉丁生化科技股份有限公司为您提供,如您想了解更多关于Erlotinib HCl (OSI-744)报价、型号、参数等信息,欢迎来电或留言咨询。
注:该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案,不可用于临床诊断或治疗等相关用途