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激酶
Crenolanib (CP-868596)
品牌 | 厂商性质 | 产地 | 货期 |
---|---|---|---|
阿拉丁 | 生产商 | 上海 | 现货 |
产品参数
货号 | CAS号 | 操作 |
---|---|---|
C127776-50mg | 670220-88-9 | 询价 |
C127776-5mg | 670220-88-9 | 询价 |
C127776-10mg | 670220-88-9 | 询价 |
产品介绍
- 分子式 C26H29N5O2
- 分子量443.54
属性
溶解性 |
|
存贮条件 | 储存温度-20°C |
描述
备注 | Crenolanib (CP-868596) is a potent and selective inhibitor of PDGFRα/β with Kd of 2.1 nM/3.2 nM, also potently inhibits FLT3, sensitive to D842V mutation not V561D mutation, >100-fold more selective for PDGFR than c-Kit, VEGFR-2, |
生化机理 |
Crenolanib (CP-868569) is a highly selective and potent PDGFR-α inhibitor with IC50 of 0.9 and 1.8 nM against PDGFRα and PDGFRβ, respectively. In addition,Crenolanib (CP-868569) inhibits the activity of PDGFRα D842V kinase with an IC50 of 1 nM. |
别名 | 1-(2-(5-((3-methyloxetan-3-yl)methoxy)-1H-benzo[d]imidazol-1-yl)quinolin-8-yl)piperidin-4-amine;1-(2-(5-((3-methyloxetan-3-yl)methoxy)-1H-benzo[d]imidazol-1-yl)quinolin-8-yl)piperidin-4-amine |
Crenolanib (CP-868596)信息由上海阿拉丁生化科技股份有限公司为您提供,如您想了解更多关于Crenolanib (CP-868596)报价、型号、参数等信息,欢迎来电或留言咨询。
注:该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案,不可用于临床诊断或治疗等相关用途