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Cabozantinib (XL184, BMS-907351)
品牌 | 厂商性质 | 产地 | 货期 |
---|---|---|---|
阿拉丁 | 生产商 | 上海 | 现货 |
产品参数
货号 | CAS号 | 操作 |
---|---|---|
C126195-100mg | 849217-68-1 | 询价 |
C126195-10mg | 849217-68-1 | 询价 |
C126195-250mg | 849217-68-1 | 询价 |
C126195-50mg | 849217-68-1 | 询价 |
C126195-5mg | 849217-68-1 | 询价 |
产品介绍
属性
溶解性 | Soluble in DMSO (100 mg/ml at 25 °C), water (<1 mg/ml at 25 °C), ethanol (<1 mg/ml at 25 °C), and 30% propylene glycol, 5% Tween 80, 65% D5W (30 mg/ml at 25 °C). |
存贮条件 | 储存温度-20°C |
描述
应用 | A potent VEGFR2 and Met inhibitor |
产品介绍 | Cabozantinib (XL184, BMS-907351)是一种有效的VEGFR2抑制剂,靶向作用于VEGFR2和c-Met时,IC50为0.035 nM ,也有效抑制c-Met、 Ret、 Kit、Flt-1/3/4、Tie2和AXL,IC50分别为1.3 nM, 4 nM, 4.6 nM, 12 nM/11.3 nM/6 nM, 14.3 nM and 7 nM。 |
备注 | Cabozantinib (XL184, BMS-907351) is a potent VEGFR2 inhibitor with IC50 of 0.035 nM and also inhibits c-Met, Ret, Kit, Flt-1/3/4, Tie2, and AXL with IC50 of 1.3 nM, 4 nM, 4.6 nM, 12 nM/11.3 nM/6 nM, 14.3 nM and 7 nM, respectively.Phas |
生化机理 | XL184 (Cabozantinib) is a potent VEGFR2 inhibitor with IC50 of 0.035 nM. XL-184 also displays potent activity against Met, Ret, Kit, FLT1, FLT3, FLT4, Tie2, and AXL. XL184 at low concentration (0.1-0.5 μM) is sufficient to induce marked inhibition of constitutive and inducible Met phosphorylation and its resultant downstream signaling in MPNST cells, and inhibit HGF-induced MPNST cell migration and invasion. |
别名 | BMS-907351;博卡替尼;卡博替尼;卡赞替尼;N-[4-[(6,7-二甲氧基-4-喹啉基)氧基]苯基]-N'-(4-氟苯基)-1,1-环丙烷二甲酰胺;XL184; BMS-907351; XL-184; XL184;N-[4-[(6,7-Dimethoxy-4-quinolinyl)oxy]phenyl]-N'-(4-fluorophenyl)-1,1-cyclopropanedicarboxamide |
Cabozantinib (XL184, BMS-907351)信息由上海阿拉丁生化科技股份有限公司为您提供,如您想了解更多关于Cabozantinib (XL184, BMS-907351)报价、型号、参数等信息,欢迎来电或留言咨询。
注:该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案,不可用于临床诊断或治疗等相关用途