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CP-673451
品牌 | 厂商性质 | 产地 | 货期 |
---|---|---|---|
阿拉丁 | 生产商 | 上海 | 现货 |
产品参数
货号 | CAS号 | 操作 |
---|---|---|
C125124-100mg | 343787-29-1 | 询价 |
C125124-1mg | 343787-29-1 | 询价 |
C125124-25mg | 343787-29-1 | 询价 |
C125124-5mg | 343787-29-1 | 询价 |
产品介绍
属性
溶解性 |
|
存贮条件 | 储存温度-20°C |
描述
产品介绍 | CP 673451是PDGFRα和β选择性抑制剂,IC50分别为10 nM和1 nM,比对其它血管生成受体的抑制性强450倍,有抗血管生成和抗肿瘤活性。 |
备注 | CP 673451 is a selective inhibitor of PDGFRα/β with IC50 of 10 nM/1 nM, exhibits >450-fold selectivity over other angiogenic receptors, has antiangiogenic and antitumor activity. |
生化机理 |
CP-673451 is a potent PDGFR-β inhibitor with an IC50 of 1 nM. A dose of 33 mg/kg was adequate to provide >50% inhibition of receptor for 4 hours corresponding to an EC50 of 120 ng/mL in plasma at Cmax. In a sponge angiogenesis model, CP-673451 inhibited 70% of PDGF-BB-stimulated angiogenesis at a dose of 3 mg/kg (q.d. × 5, p.o., corresponding to 5.5 ng/mL at Cmax). CP-673451 did not inhibit vascular endothelial growth factor- or basic fibroblast growth factor-induced angiogenesis at concentrations which inhibited tumor growth. |
别名 | CP 673451;CP673451; 1-(2-(5-(2-甲氧基乙氧基)苯并咪唑-1-基)喹啉-8-基)哌啶-4-基胺;;CP 673451; CP673451; 1-(2-(5-(2-methoxyethoxy)benzimidazol-1-yl)quinolin-8-yl)piperidin-4-ylamine |
CP-673451信息由上海阿拉丁生化科技股份有限公司为您提供,如您想了解更多关于CP-673451报价、型号、参数等信息,欢迎来电或留言咨询。
注:该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案,不可用于临床诊断或治疗等相关用途