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ZM 323881 HCl
品牌 | 厂商性质 | 产地 | 货期 |
---|---|---|---|
阿拉丁 | 生产商 | 上海 | 现货 |
货号 | CAS号 | 操作 |
---|---|---|
Z129761-10mg | 193000-39-4 | 询价 |
Z129761-1mg | 193000-39-4 | 询价 |
Z129761-50mg | 193000-39-4 | 询价 |
属性
溶解性 |
|
存贮条件 | 储存温度-20°C |
描述
备注 | ZM 323881 is a potent and selective VEGFR2 inhibitor with IC50 of <2 nM, almost no activity on VEGFR1, PDGFRβ, FGFR1, EGFR and ErbB2. |
生化机理 |
Description: IC50 Value: <2nM( for VEGFR2) ZM323881 is a novel VEGF-R2 selective inhibitor, which has a potent and selective inhibitor of VEGF-R2 tyrosine kinase in vitro (IC(50) < 2 nM), compared with other receptor tyrosine kinases, including VEGF-R1 (IC(50) > 50 microM) [1]. M323881 inhibited activation of VEGFR-2, but not of VEGFR-1, epidermal growth factor receptor (EGFR), platelet-derived growth factor receptor (PDGFR), or hepatocyte growth factor (HGF) receptor [2]. in vitro: ZM323881 inhibits VEGF-A-induced endothelial cell proliferation (IC(50) = 8 nM) and VEGF-R2 tyrosine phosphorylation in vitro[1]. The VEGF-induced elevation of LpA/Vi was blocked by the selective VEGF-R2 inhibitor ZM323881 [3]. Stimulation of FTC133 cells with exogenous VEGF enhanced ID3 expression, which could be abrogated by the inhibitor ZM323881 [4]. in vivo: VEGF-A-mediated increases in vascular permeability in perfused mesenteric microvessels in vivo were reversibly abolished |
别名 | Phenol, 4-fluoro-2-methyl-5-[[7-(phenylmethoxy)-4-quinazolinyl]amino]-, hydrochloride (1:1);Phenol, 4-fluoro-2-methyl-5-[[7-(phenylmethoxy)-4-quinazolinyl]amino]-, hydrochloride (1:1) |
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注:该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案,不可用于临床诊断或治疗等相关用途