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WZ8040
| 品牌 | 厂商性质 | 产地 | 货期 |
|---|---|---|---|
| 阿拉丁 | 生产商 | 上海 | 现货 |
产品参数
| 货号 | CAS号 | 操作 |
|---|---|---|
| W126471-1mg | 1214265-57-2 | 询价 |
| W126471-25mg | 1214265-57-2 | 询价 |
| W126471-50mg | 1214265-57-2 | 询价 |
| W126471-5mg | 1214265-57-2 | 询价 |
产品介绍
属性
| 溶解性 | DMSO ≥93mg/mL Water <1.2mg/mL Ethanol ≥2.8mg/mL |
| 存贮条件 | 储存温度-20°C |
描述
| 应用 | A potent inhibitor of EGFR T790M |
| 产品介绍 | WZ8040是突变选择型不可逆EGFRT790M抑制剂，对ERBB2磷酸化(T798I)无抑制性。 |
| 备注 | WZ8040 is a novel mutant-selective irreversible EGFRT790M inhibitor, does not inhibit ERBB2 phosphorylation (T798I). |
| 生化机理 | WZ8040 is 30- to 100-fold more potent against EGFR T790M, and up to 100-fold less potent against wild-type EGFR, than quinazoline-based EGFR inhibitors such as CL-387785 and HKI-272. WZ8040 treatment potently inhibits the growth of HCC827 (EGFR Del E746_A750), PC9 (EGFR Del E746_A750), H3255 (EGFR L858R), H1975 (EGFR L858R/T790M), and PC9 GR (EGFR Del E746_A750/T790M) with IC50 of 1 nM, 6 nM, 66 nM, 9 nM, and 8 nM, respectively. WZ8040 weakly inhibits the growth of HCC827 GR (EGFR E746_A750/MET amp), H1819 (ERBB2 amp), Calu-3 (ERBB2 amp), H1781 (ERBB2 Ins G776V, C), and HN11 (EGFR & ERBB2 WT) with IC50 of >3.3 μM, 738 nM, 915 nM, 744 nM, and 1.82 μM, respectively. WZ8040 is not toxic up to 10 μM against A549 (KRAS mutant) or H3122 (EML4-ALK) cells. |
| 别名 | WZ-8040; WZ 8040；N-[3-[[5-氯-2-[[4-(4-甲基-1-哌嗪基)苯基]氨基]-4-嘧啶基]硫基]苯基]-2-丙烯酰胺;WZ-8040;WZ 8040；N-[3-[[5-Chloro-2-[[4-(4-methyl-1-piperazinyl)phenyl]amino]-4-pyrimidinyl]thio]phenyl]-2-propenamide |
WZ8040信息由上海阿拉丁生化科技股份有限公司为您提供，如您想了解更多关于WZ8040报价、型号、参数等信息，欢迎来电或留言咨询。
注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途