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Minisite
激酶
TAE684 (NVP-TAE684)
品牌 | 厂商性质 | 产地 | 货期 |
---|---|---|---|
阿拉丁 | 生产商 | 上海 | 现货 |
产品参数
货号 | CAS号 | 操作 |
---|---|---|
T129819-50mg | 761439-42-3 | 询价 |
T129819-5mg | 761439-42-3 | 询价 |
T129819-10mg | 761439-42-3 | 询价 |
产品介绍
- 分子式 C30H40ClN7O3S
- 分子量614.20
属性
溶解性 | DMSO 3 mg/mL Water <1 mg/mL Ethanol <1 mg/mL |
存贮条件 | 储存温度-20°C |
描述
应用 | A selective NPM-ALK phosphorylation inhibitor which also inhibits ALK and LRRK2 Kinase |
产品介绍 | TAE684 (NVP-TAE684)是一种有效的,选择性的ALK抑制剂,IC50为3 nM,作用于ALK比作用于InsR选择性高100倍。 |
备注 | TAE684 is a potent and selective ALK inhibitor with IC50 of 3 nM, 100-fold more sensitive for ALK than InsR. |
生化机理 | TAE684 selectively inhibits the phosphorylation of NPM-ALK, inducing apoptosis and G1 phase arrest in Ba/F3 cell lines. TAE684 potently inhibits the proliferation of Ba/F3 NPM-ALK cells with IC50 of 3 nM, without affecting the survival of Ba/F3 cells even at 1 μM. TAE684 also inhibits proliferation of NPM-ALK-expressing human ALCL cell lines including Karpas-299 and SU-DHL-1 with IC50 of 2–5 nM. |
别名 | NVP-TAE684; 5-氯-N2-[2-甲氧基-4-[4-(4-甲基-1-哌嗪基)-1-哌啶基]苯基]-N4-[2-[(1-甲基乙基)磺酰基]苯基]-2,4-嘧啶二胺;5-Chloro-N2-[2-methoxy-4-[4-(4-methyl-1-piperazinyl)-1-piperidinyl]phenyl]-N4-[2-[(1-methylethyl)sulfonyl]phenyl]-2,4-pyrimidinediamine; NVP-TAE684 |
TAE684 (NVP-TAE684)信息由上海阿拉丁生化科技股份有限公司为您提供,如您想了解更多关于TAE684 (NVP-TAE684)报价、型号、参数等信息,欢迎来电或留言咨询。
注:该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案,不可用于临床诊断或治疗等相关用途