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激酶
Tyrphostin AG 879
| 品牌 | 厂商性质 | 产地 | 货期 |
|---|---|---|---|
| 阿拉丁 | 生产商 | 上海 | 现货 |
产品参数
| 货号 | CAS号 | 操作 |
|---|---|---|
| T129799-5mg | 148741-30-4 | 询价 |
| T129799-100mg | 148741-30-4 | 询价 |
| T129799-25mg | 148741-30-4 | 询价 |
产品介绍
- 分子式 C18H24N2OS
- 分子量316.46
- MDL号 MFCD00236450
- PubChem编号 24278728
属性
| 沸点 | ~443.81° C at 760 mmHg |
| 熔点 | 219-220° C |
| 折光率 | 1.61 |
| 溶解性 |
|
| 存贮条件 | 储存温度-20°C |
描述
| 应用 | A protein tyrosine kinase inhibitor with potent effects on TrkA |
| 产品介绍 | AG879是酪氨酸激酶的抑制剂，能够抑制TrKA的磷酸化，但不能抑制TrKB 和TrKC，也是高选择性的ErbB2激酶抑制剂。 |
| 备注 | Tyrphostin AG 879 potently inhibits HER2/ErbB2 with IC50 of 1 μM, 100- and 500-fold higher selective to ErbB2 than PDGFR and EGFR. |
| 生化机理 | Tyrphostin AG 879 is a protein tyrosine kinase inhibitor with potent effects on TrkA. This product reportedly inhibits NGF-induced PLC-γ 1 phosphorylation and phosphatidylinositol-3 kinase activation. Has been shown in lab studies to disrupt Sertoli cell aggregation and stop androgen-induced cell proliferation. AG 879 also displays anti-cancer effects by inhibiting the expression of RAF-1 gene encoding MAP kinase activity necessary for human breast cancer cell proliferation. Shown to inhibit Neu (HER-2 or ERBB2) expression and reduced tumor sizes in mice leukemia cells. Tyrphostin AG 879 is an inhibitor of Flk-1. |
| 别名 | AG 879；AG-879；AG879;AG 879；AG-879；AG879； α-Cyano-(3,5-di-t-butyl-4-hydroxy)thiocinnamide； (E)-3-[3,5-Bis(1,1-dimethylethyl)-4-hydroxyphenyl]-2-cyano-2-propenethioamide |
Tyrphostin AG 879信息由上海阿拉丁生化科技股份有限公司为您提供，如您想了解更多关于Tyrphostin AG 879报价、型号、参数等信息，欢迎来电或留言咨询。
注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途