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Tyrphostin 23

品牌 厂商性质 产地 货期
阿拉丁 生产商 上海 现货

询价
产品参数
货号 CAS号 操作
T129445-50mg 118409-57-7 询价
T129445-250mg 118409-57-7 询价
T129445-10mg 118409-57-7 询价
产品介绍

属性

沸点 ~421.15° C at 760 mmHg
折光率 1.70
溶解性
  • DMSO 37 mg/mL
  • Water <1 mg/mL
  • Ethanol 37 mg/mL
    • 存贮条件 储存温度-20°C
    密度 1.4000

    描述

    应用 Tyrphostin 23 can be used as a tyrosine kinase inhibitor for studying rat ghrelin-induced MAPK stimulation in GH3 cells. Tyrphostin 23 has also been used to analyze its effects on secretoneurin (SN)-induced chemotaxis of neutrophils。
    产品介绍 AG-18(RG-50810; Tyrphostin A23)抑制EGFR，IC50为40 μM。
    生化机理 Tyrphostin A23, also known as tyrphostin-23, belongs to a novel class of low molecular weight proteins that inhibit protein tyrosine kinase and block the EGF-dependent autophosphorylation of the receptor. The inhibitors can bind to the EGF receptor kinase domain with different affinities. It also inhibits PDGFR kinase. Tyrphostin A23 has been used to inhibit agonist-induced GP IIb-IIIa activation in permeabilized platelets and in other studies to block calcium channel currents in vascular smooth muscle cells. In human and rat adrenocrotical cell studies tyrphostin-A23 can improved steroid-hormone secretion. Tyrphostin A23 can also inhibit the internalization of (125)I-transferrin in Heb7a cells.
    别名 AG 18; AG-18; AG18；(3,4-二羟基亚苄基)丙二腈;Tyrphostin A23; AG 18; AG-18; AG18; RG 50810; RG50810； TX 825; Tyrphostin AG 18；Tyrphostin AG-18；(3,4-Dihydroxybenzylidene)malononitrile ；2-(3,4-Dihydroxybenzylidene)malononitrile;

    Tyrphostin 23信息由上海阿拉丁生化科技股份有限公司为您提供，如您想了解更多关于Tyrphostin 23报价、型号、参数等信息，欢迎来电或留言咨询。

    注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途