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Axitinib
| 品牌 | 厂商性质 | 产地 | 货期 |
|---|---|---|---|
| 阿拉丁 | 生产商 | 上海 | 现货 |
产品参数
| 货号 | CAS号 | 操作 |
|---|---|---|
| A129732-10mg | 319460-85-0 | 询价 |
| A129732-50mg | 319460-85-0 | 询价 |
| A129732-1g | 319460-85-0 | 询价 |
| A129732-250mg | 319460-85-0 | 询价 |
产品介绍
- 分子式 C22H18N4OS
- 分子量386.47
- Beilstein号
- EC号
- MDL号 MFCD09837898
- PubChem编号
属性
| 溶解性 | Soluble in DMSO (42 mg/ml at 25 °C), water (<1 mg/ml at 25 °C), ethanol (<1 mg/ml at 25 °C), methanol, and DMF (~0.25 mg/ml)., |
| 存贮条件 | 储存温度-20°C |
描述
| 应用 | An inhibitor of Flt and Flk (VEGFR) with antitumor properties |
| 产品介绍 | Axitinib is a non-selective receptor kinase inhibitor of Flt and Flk proteins. This compound also inhibits Flt-1(VEGFR-1), Flk-1(VEGFR-2), Flt-4(VEGFR-3), PDGFR-β and c-Kit(c-KIT) with IC50 of 0.1 nM, 0.2 nM, 0.1-0.3 nM, 1.6 nM and 1.7 nM, respectively. Axitinib is studied as an antitumor agent of various cell lines. Axitinib is an inhibitor of PDGFR-β. |
| 合法信息 | Sold for research purposes under agreement from Pfizer Inc. - Not for human or veterinary use. |
| 备注 | Axitinib is a multi-target inhibitor of VEGFR1, VEGFR2, VEGFR3, PDGFRβ and c-Kit with IC50 of 0.1 nM, 0.2 nM, 0.1-0.3 nM, 1.6 nM and 1.7 nM, respectively. |
| 生化机理 | Axitinib blocked phosphorylation of VEGFR-2 and VEGFR-3 with average IC50s of 0.2 and 0.1 to 0.3 nM. |
| 别名 | AG 013736;阿西替尼;AG-013736; N-Methyl-2-((3-((1E)-2-(pyridin-2-yl)ethenyl)-1H-indazol-6-yl)sulfanyl)benzamide; |
Axitinib信息由上海阿拉丁生化科技股份有限公司为您提供，如您想了解更多关于Axitinib报价、型号、参数等信息，欢迎来电或留言咨询。
注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途