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激酶
AG-1478 (Tyrphostin AG-1478)
| 品牌 | 厂商性质 | 产地 | 货期 |
|---|---|---|---|
| 阿拉丁 | 生产商 | 上海 | 现货 |
产品参数
| 货号 | CAS号 | 操作 |
|---|---|---|
| A126582-25mg | 153436-53-4 | 询价 |
| A126582-50mg | 153436-53-4 | 询价 |
| A126582-10mg | 153436-53-4 | 询价 |
| A126582-5mg | 153436-53-4 | 询价 |
产品介绍
- 分子式 C16H14ClN3O2
- 分子量315.75
属性
| 溶解性 | 25°C: DMSO 25 mg/mL; Water <1 mg/mL; Ethanol 13 mg/mL |
| 存贮条件 | 储存温度-20°C |
| 密度 | 1.3370 |
描述
| 产品介绍 | AG-1478 (NSC 693255)是高效EGFR选择性抑制剂，IC50为3 nM，对HER2-Neu，PDGFR，Trk，Bcr-Abl和InsR无活性。 |
| 备注 | AG-1478 (Tyrphostin AG-1478) is a selective EGFR inhibitor with IC50 of 3 nM, almost no activity on HER2-Neu, PDGFR, Trk, Bcr-Abl and InsR. |
| 生化机理 |
AG1478 inhibited EGFR phosphorylation in CNE2 cells without reduced expression of EGFR protein. The activation of Akt and MAPK which are downstream molecules of EGFR signaling pathway, were also inhibited by AG1478 . Although AG 1478 inhibited cell growth, DNA synthesis, EGFR tyrosine kinase activity, and receptor autophosphorylation of each cell line in a dose-dependent manner, it was significantly more potent in U87MG. delta EGFR cells than in the other two cell lines . in vivo: At the lowest dose, plasma drug levels after the cessation of infusion declined with a half-life of approximately 43 min. EGFR activity, measured both by autophosphorylation and downstream signalling, was inhibited in a dose-dependent manner by injection of AG1478 in mice bearing xenografts of the human glioblastoma cell line U87MG |
| 别名 | 酪氨酸激酶抑制剂AG 1478; N-(3-氯苯基)-6,7-二甲氧基-4-氨基喹唑啉;(3-氯苯基)(6,7-二甲氧基喹唑啉-4-基)胺 ;Tyrphostin AG-1478;AG 1478;NSC 693255;AG1478;N-(3-Chlorophenyl)-6,7-dimethoxy-4-quinazolinamine;3-chlorophenyl)(6,7-dimethoxyquinazolin-4-yl)amine |
AG-1478 (Tyrphostin AG-1478)信息由上海阿拉丁生化科技股份有限公司为您提供，如您想了解更多关于AG-1478 (Tyrphostin AG-1478)报价、型号、参数等信息，欢迎来电或留言咨询。
注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途