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激酶
AMG-208
品牌 | 厂商性质 | 产地 | 货期 |
---|---|---|---|
阿拉丁 | 生产商 | 上海 | 现货 |
产品参数
货号 | CAS号 | 操作 |
---|---|---|
A127592-10mg | 1002304-34-8 | 询价 |
A127592-50mg | 1002304-34-8 | 询价 |
产品介绍
- 分子式 C22H17N5O2
- 分子量383.41
属性
溶解性 |
|
存贮条件 | 储存温度-20°C |
描述
应用 | A highly selective Met inhibitor (IC50 = 9.3 nM) |
产品介绍 | AMG-208是c-Met抑制剂,IC50为9.3 nM。 |
备注 | AMG 208 is a highly selective c-Met inhibitor with IC50 of 9 nM. Phase 1. |
生化机理 | AMG-208 shows the potent inhibition of kinase c-Met activity with IC50 of 9 nM in a cell-free assay. Besides, AMG-208 treatment also leads to the inhibition of HGF-mediated c-Met phosphorylation in PC3 cells with IC50 of 46 nM . Pre-incubation of AMG-208 with human liver microsomes for 30 minutes shows a potent time-dependent inhibition for CYP3A4 metabolic activity with IC50 of 4.1 μM, which is an eightfold decrease relative to the IC50 (32 μM) without preincubation . AMG-208 is identified to be a c-MET and RON dual selective inhibitor |
别名 | AMG208; AMG 208; 7-甲氧基-4-((6-苯基-1,2,4-三唑并(4,3-b)哒嗪-3-基)甲氧基)喹啉;;AMG208; AMG 208;7-methoxy-4-((6-phenyl-1,2,4-triazolo(4,3-b)pyridazin-3-yl)methoxy)quinoline |
AMG-208信息由上海阿拉丁生化科技股份有限公司为您提供,如您想了解更多关于AMG-208报价、型号、参数等信息,欢迎来电或留言咨询。
注:该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案,不可用于临床诊断或治疗等相关用途